Table 7.

IC cytokine expression by CD3+ T cells in BAL at days 3 and 6 after a primary or secondary infection with B1 or CP52

InfectionaInfectionChallengeMean % positive IC cytokine expression ± SEMb
Day 3 p.i.Day 6 p.i.
IL-2IL-4IL-5IL-6IL-12IFN-γTNF-αIL-2IL-4IL-5IL-6IL-12IFN-γTNF-α
PrimaryB1None7 ± 35 ± 220 ± 624 ± 67 ± 216 ± 912 ± 37 ± 217 ± 425 ± 528 ± 75 ± 219 ± 516 ± 6
CP52None2 ± 211 ± 46 ± 310 ± 55 ± 236 ± 535 ± 1113 ± 417 ± 511 ± 317 ± 312 ± 641 ± 918 ± 7
SecondaryB1B15 ± 319 ± 719 ± 69 ± 411 ± 410 ± 343 ± 126 ± 215 ± 48 ± 213 ± 28 ± 26 ± 228 ± 4
B1CP5210 ± 212 ± 214 ± 412 ± 49 ± 39 ± 445 ± 816 ± 88 ± 26 ± 36 ± 310 ± 310 ± 433 ± 4
CP52B18 ± 310 ± 416 ± 95 ± 27 ± 37 ± 332 ± 104 ± 28 ± 29 ± 34 ± 26 ± 36 ± 336 ± 6
CP52CP5212 ± 36 ± 29 ± 39 ± 313 ± 310 ± 332 ± 910 ± 46 ± 24 ± 28 ± 210 ± 48 ± 228 ± 8
  • a Mice were i.n. immunized with 104 PFU of B1 or CP52, rested, and then challenged with 104 PFU of either B1 or CP52.

  • b For three individual experiments, three mice per experiment.