Table 4.

Summary of consistent amino acid changes between Southeast Asian and American genotype viruses

GenePosition no.Change of amino acida
ThNHp11 (DF)K00010 (DF)CO371 (DF)CO166 (DF)ThNH7 (DSS)bK0008 (DHF)CO390 (DHF)CO167 (DHF)Mara4 (DHF)102692 (DHF)Ven2 (DF)0131 (DF)IQT1797 (DF)IQT2913 (DF)
prM28EEEEEEEEEEKKKK
31VVVVVVVVVV T T T T
E390NNNNNNNNNNDDDD
NS1128SSSSSSSSSS L L L L
NS3567IIIIIIIIII T T T T
NS4b17SSSSSSSSSSHHHH
NS5271IIIIIIIII T T T T
645NNNNNNNNNDDDD
676SSSSSSSSSRRKK
800KKKKKKKKKSSSS
819QQQQQQQQQ L L L L
  • a Charge changes are italicized, and side chain changes are in boldface. Negative charge amino acids, E (glutamic acid) and D (aspartic acid); positive charge amino acids, K (lysine), H (histidine), and R (arginine); neutral amino acids with polar side chains, V (valine), L (leucine), and I (isoleucine); neutral amino acids with nonpolar side chains, T (threonine), N (asparagine), S, (serine), and Q (glutamine). —, not done.

  • b DSS, dengue shock syndrome.