Table 2.

Results of PBMC coculture, PCR for viral DNA, and seroconversion to p27 antigen

MonkeyAntibody receivedPBMC coculturea at wk:Virus in necropsy PCRbof:Anti-p27 Abc
0123457912IngAxSplMesThy
JEFIVIG++++NDd ++++++++
ADIKIVIG++++ND+++ND++++
AK42IVIG++++ND+++NDND++ND
FDTHIVIG/2F5/2G12
KBEHIVIG/2F5/2G12
AK40HIVIG/2F5/2G12+++++++++++++
400IVIG++++++++NDND++ND
401IVIG++++++++NDND++ND
403IVIG++++++++NDND++ND
402HIVIG/2F5/2G12+++++++++++++
404HIVIG/2F5/2G12
405HIVIG/2F5/2G12++++++++++++
406HIVIG+++++++++++ND++
407HIVIG++++++++++++++
408HIVIG++++++++ND+++++
4092F5++++++++NDND+NDND
4102F5++++++++NDND++ND
4112F5++++++++++++++
4122G12++++++++++++++
4132G12++++++++++++++
4142G12++++++++++++++
4232F5/2G12+++++++++++++
4252F5/2G12+++++++ND++++
4262F5/2G12++ND
  • a PBMC cocultures are positive or negative as indicated for 0 to 12 weeks after SHIV-challenge.

  • b gag PCR performed on viable tissue collected at necropsy; Ing, inuinal lymph node; Ax, axillary lymph node; Spl, spleen; Mes, mesenteric lymph node; Thy, thymus.

  • c Seroconversion to p27 antigen measured by ELISA. Note that IVIG control animals displayed rapid CD4 cell loss and did not make anti-p27 antibody. In contrast, most antibody-treated animals that became SHIV infected did seroconvert to p27 antigen. Animals FDT, KBE, and 404 (sterile protection) and animal 426 (transient infection) did not seroconvert.

  • d ND, not done.