Table 2.

Comparison of RRV, KSHV, and HVS ORFsa

ORFbRRVKSHVHVSPutative functionc
StartStopStrandSize (aa)Size (aa)% Sim% IdSize (aa)% Sim% Id
R11 5131784+423
ORF 22418185218821055.146.018765.654.8DHFR
ORF 42 28364773+64555040.935.736042.035.3Complement binding protein
28744.038.6
ORF 652058603+1,1321,13371.363.31,12865.253.5ssDBP
ORF 7862810688+68669560.151.567958.147.7Transport protein
ORF 81067513164+82984573.365.580862.453.1gB
ORF 91328216326+1,0141,31275.067.01,00971.062.5Pol
ORF 101642117575+38441843.534.840733.623.3
ORF 111768118910+40940741.331.740546.332.4
R21 1970519082207vIL-6
ORF 70209391993833333772.166.129472.164.6TS
R33 21753214061159541.932.3vMIP
ORF 162600726570+18717558.046.016031.421.4Bcl-2 homolog
ORF 17282862667653655350.644.347549.042.2Capsid protein
ORF 182815929058+29925768.158.025660.248.8
ORF 19307092906654754961.152.854355.546.9Tegument protein
ORF 20312563020435032051.844.730343.235.6
ORF 213125532928+55758054.044.652739.031.7Thymidine kinase
ORF 223291535029+70473050.140.771742.331.5gH
ORF 23362343502640240456.848.525340.529.8
ORF 24384823628473275266.358.773156.346.8
ORF 253848442620+1,3781,37679.972.51,37176.767.5MCP
ORF 264265243575+30730571.864.330469.158.2Capsid protein
ORF 274360044409+26929033.625.328035.027.1
ORF 284457544850+9110230.126.593
ORF 29b459464490034835177.666.438774.462.9Packaging protein
ORF 304607246302+767751.338.27540.329.2
ORF 314626046913+21722456.045.420850.539.9
ORF 324685048244+46445449.941.844143.234.1
ORF 334821649226+33631252.142.133049.139.1
ORF 29a501274914732731266.761.230357.849.8Packaging protein
ORF 345012651109+32732758.948.531653.740.6
ORF 355109051539+14915147.735.615051.037.4
ORF 365144552752+43544456.046.143138.428.7Kinase
ORF 375273354175+48048672.463.548363.053.2Alkaline exonuclease
ORF 385413054339+696156.745.06639.434.8
ORF 39555585442237839973.059.336667.157.0gM
ORF 405569357099+46845742.232.745039.128.1Helicase-primase
ORF 415708457695+20320533.526.016137.329.1Helicase-primase
ORF 42585105769227227856.846.126551.238.1
ORF 43601945846457660569.761.656366.456.6Capsid protein
ORF 446013362505+79078873.966.078171.162.6Helicase-primase
ORF 45636046254635240731.224.9257
ORF 46644136364625525571.960.125267.559.1UDG
ORF 47648986438916916731.927.714133.323.9gL
ORF 48663356516638940236.229.279734.125.8
ORF 49674706656530130266.154.230335.123.3
ORF 506766169205+51463146.637.853529.721.6Transactivator
ORF 52719907157113913158.545.411541.730.4
ORF 53723687205410411051.046.29043.328.9
ORF 547244473316+29031848.641.028746.536.4dUTPase
ORF 55740097337721022762.955.220052.544.4
ORF 567402176507+82884361.252.583554.043.6DNA replication protein
ORF 577674878076+44227560.647.141640.331.5Immediate-early protein
R64 796837843641544926.021.1vIRF
R74 811037985641544928.320.7vIRF
R84 824878143235144928.919.4vIRF
R94 8342282661253vIRF
R104 853798422238544933.726.2vIRF
R114 866978552539044930.021.8vIRF
R124 8813187064355vIRF
R134 8938688292364vIRF
ORF 58907148963236035745.238.235739.929.5
ORF 59919099072539439660.351.836840.732.7DNA replication protein
ORF 60929829203831430578.270.030571.062.4Ribonucleotide reductase, small
ORF 61953309296478879269.361.776764.453.3Ribonucleotide reductase, large
ORF 62963289533333133164.456.533053.841.9Assembly/DNA maturation
ORF 639632799146+93992751.842.689943.434.6Tegument protein
ORF 6499150106796+2,5482,63549.640.22,46939.229.4Tegument protein
ORF 6510731610680716917048.238.613941.033.1Capsid protein
ORF 6610866810732244842951.946.443543.632.3
ORF 6710936810869422427169.664.725358.651.4Tegument protein
ORF 68109779111152+45754553.244.843653.544.3Glycoprotein
ORF 69111174112067+29722573.165.526157.549.0
ORF 7111890511838117413938.830.916725.315.1FLIP homolog
ORF 7211972811896425425749.838.625437.529.2Cyclin D homolog
ORF 731213791200364471,16223.616.840729.020.8Latency-associated nuclear antigen
R155 122033122794+25334835.231.2N-CAM Ox-2 homolog
ORF 74123091124119+34234251.641.132141.132.1G-protein coupled receptor
ORF 751281201242241,2981,29652.244.01,29943.234.4Tegument protein/FGARAT
  • a Sim, similar; Id, identical; aa, amino acids.

  • b 1, no similarity found; 2, compared to HVS ORF 4a and 4b; 3, compared to KSHV R4; 4, compared to KSHV K9; 5, compared to KSHV K14.

  • c FGARAT, N-formalglycinamide ribotide amidotransferase.