Table 3.

Comparison of estimated mutation rates for various influenza virus strains

VirusReferenceAssayGeneMutation rate (bp/site/replication)
A/Victoria/3/75 (H3N2) 28 Monoclonal antibody escapeHA1.0 × 10−5
A/WSN/33 (H1N1) 21;2Direct sequencing of RNANS0.84 × 10−5
A/Mallard/New York/6750/78 (H2N2)This studyAmantadine escapeM3.2 × 10−5
A/Swine/Germany/2/81 (H1N1)This studyAmantadine escapeM0.68 × 10−5