Table 3.

Insensitivity of T134 to AMD3100-resistant virus

CompoundEC50(nM)a
A018AA031-1A031-2
T13418.519.128.6
AMD310049.01,000.01,330.0
Zidovudine50.624.016.2
  • a The EC50 was calculated on the basis of the reduction in the number of blue cells induced by wild-type HIV-1 (A018A) and AMD3100-resistant HIV-1 isolates (A031-1 and A031-2) in the MAGI assay.