Table 1.

Lymph node lymphocytes of SIVmac-infected rhesus monkeys demonstrate Gag epitope-specific CTL function

Monkeya% p11C, C-Mb-specific lysisc
PBLLymph node
ConA–IL-2 expanded (50/25/13)dp11C, C-M expanded (5/3/1)ConA–IL-2 expanded (50/25/13)p11C, C-M expanded (5/3/1)
GL913/07/0440/35/3057/52/3927/21/15
3K125/16/0845/34/2807/04/0212/07/05
40343/40/3260/60/5641/34/29NTe
13818/13/0668/66/5850/46/4038/34/26
57511/07/0514/09/0508/04/0116/10/06
15439/27/1460/58/4815/08/04NT
  • a Chronically SIVmac-infected, Mamu-A*01+ rhesus monkeys.

  • b p11C, C-M represents the optimal 9-amino-acid fragment of the SIV Gag 12-amino-acid peptide p11C.

  • c Percent p11C, C-M-specific lysis was calculated as percent specific release by p11C, C-M-pulsed MHC class I-matched target cells minus the average of the percent release by control peptide p11B-pulsed target cells. The background level of p11B peptide-specific lysis was always less than 5% of the spontaneous release.

  • d E/T ratio.

  • e NT, not tested.