Table 2.

In vivo epinephrine-induced ocular reactivation in latently infected rabbitsa

Virus or P value comparisonNo. of virus-positive rabbitsb/total no. of rabbits (%) or P valueNo. of virus-positive eyes/total no. of eyes (%) or P valueNo. of virus-positive eye swabs/total no. of eye swabs (%) or P value
Viruses
 McKrae4/7 (57)7/14 (50)23/98 (24)
dLAT3717/7 (100)9/14 (64)20/98 (20)
dLAT29034/16 (25)4/32 (13)8/192 (4)
P value comparisonsc
dLAT371 vs McKrae0.19 0.70    0.73  
dLAT371 vsdLAT29030.0010.0008<0.0001
dLAT2903 vs McKrae0.18 0.01  <0.0001
Virusesc
 17syn+7/11 (64)12/22 (55)48/154 (31)
 17ΔSty2/9 (22)2/18 (11)4/126 (3)
 17ΔSty-Res5/8 (63)10/16 (63)35/112 (31)
P value comparisons
 McKrae vs 17syn+1.0  1.0     0.2   
dLAT371 vs 17ΔSty0.0030.003 <0.0001
dLAT2903 vs 17ΔSty1.0  1.0     0.77  
 17ΔSty-Res vs 17syn+1.0  0.74   1.0   
  • a Rabbits were infected with 2 × 105 PFU of the indicated virus per eye and subjected to epinephrine iontophoresis approximately 30 days p.i., and in vivo-induced reactivation was monitored by culturing tears daily for 7 consecutive days, as described previously (7). Data presentation and statistical analyses are as described for Table 1.

  • b Number of rabbits in each group that had at least one virus-positive tear culture within 7 days of induction.

  • c Data reproduced from a previous publication (7).