Table 1.

Properties of viral mutant Vmw110 proteins

VirusVmw110aHAUSP bindingbComments
17syn+1–775YesWild type
dl14031–150NoTaken as null mutant
E52X1–594No
E58X1–633No
A8X1–646Minimal
A78Δ592–646Minimal
D12Δ594–633Minimal
FXEΔ106–149YesRING finger deletion
  • a Amino acids present or deleted (Δ) from the wild-type sequence.

  • b As detected by coimmunoprecipitation. Trace amounts of HAUSP have sometimes been detected in experiments using A8X, D12, and A78, but these are very substantially reduced compared to the wild type. The data in this Table are presented in more detail elsewhere (16).