Table 2.

Nucleotide and deduced amino acid residues in the NA, M1, PB1, and PB2 proteins that correlate with mouse pathogenicity phenotypea

H5N1 virusMouse pathogenicity phenotypeNucleotide (nt) or residue (aa) at indicated position
NAM1PB1PB2
nt 668aa 223nt 68aa 15nt 617aa 198nt 975aa 317nt 1090aa 355
HK/481/97HighTIAIAKAIAK
HK/483/97HighTIAIAKAIAK
HK/485/97HighTIACCTAKAIAK
HK/491/97HighTIAIAKAIAK
HK/503/97HighTIAIAKAIAK
HK/514/97HighTIAIAKAIAK
HK/516/97HighTIAIAKAIAK
HK/532/97HighTIAIAKAIAK
HK/542/97HighTIAIAKAIAK
HK/156/97IntermediateTIAIAKAIAK
HK/486/97LowCTGVGRGMCQ
HK/488/97LowCTGVGRGMCQ
HK/507/97LowCTGVGRGMCQ
HK/538/97LowCTGVGRGMCQ
HK/97/98LowCTGVGRGMCQ