Table 1.

Binding patterns of anti-gp120 and anti-gp41 MAbs with HIV-1‚ÄČisolates

IsolateaCladeBinding (pg of p24/ml)
Anti-V3 MAbsAnti-C5 MAbsAnti-gp41 MAbsMeanb
447-52D1006-15D1027-15D908-D257-D782-D694/98-D1334453-D838-D419-D386-D412-D418-D537-D311-11D504-D268-D1324E670-D1331A989-D858-D246-D240-D181-D50-691367
CA1-R5A148100120691185752801080755504221171917019250024514180701661
VI191-R5A3949612550200336737427030860406000025212910661035
92RW021-R5A1700000003000130099001544207786619279520
CA5-R5B3901215455382484618051752555502263721680100020601577400308311966625194
MNp-X4B29916122391226775218865901267125639421113825001346587122564
JR-FL-R5B37072722616408337421035763720000136100197180164676568363
BX08-R5B10320313669112433552002652407017252216120673861552662171
BK131-R5B683950732927065430014093001568427210209961391231
IIIB-X4B1694400005200510028000110021000175205221022
SG2728-R5C2945162531453169437132503245254326421328441093826191933
2036-R5C15075572330109283785033003713145122866314289772401060
ZB18-R5C201896581614152200500000001124000208232029021
MAL-R5X4D276130862153223766216455726914060216218900245192601162
92UG021-X4D151663043245162848720022471322201014102648011419264640
92UG001-X4D534220625181574197531002136515249847128727547251
CI13-R5D74000000000000000000040028833503116
92TH009-R5E1523144021600114260440605027395100135612812022
92TH011-R5E191901910900000000005175212911721368201919
CM235-X4E530100008000000000000427192116684081314
CA4-R5F53772496220273691000507001835390222712230741431
93BR029-R5F4922534442781790920200000013165126227640451848
93BR019-R5F1023719191301900171803000012001849416712223672626
CA20-R5F34917500608110200000000000640291277
VI526-X4G43428218213138004004000141300201141230519
VI525-R5X4G09319015016902600010000261500156832702916
CA13-X4H1506063994010000300001212067132120010
‚ÄÉMeanc 11538574434392439432722261719121161265041101121712236382041
  • a Coreceptor usage is shown as a suffix for each isolate.

  • b Average binding of all 28 MAbs with each isolate.

  • c Average binding of all 26 isolates with each MAb.