Table 1.

PKR−/− or PKR+/+ mice infected i.n. with various doses of VSVa

Genetic backgroundStraini.n. dose (PFU)No. of mice surviving at day 5/total no. of mice
PKR+/+ BALB/c5 × 104 5/5
CD15 × 104 5/5
BALB/c × 1295 × 104 5/5
PKR−/− BALB/c × 1295 × 104 0/5
5 × 103 0/4
5 × 102 0/3
5 × 101 0/3
  • a PKR−/− and PKR+/+ control mice were infected i.n. with various doses, and their survival was monitored over time. All PKR−/−mice succumbed to the infection between days 2 and 5 depending on the dose, while control mice remained alive beyond this point.