Table 2.

Independent effects of coreceptor specificity and T-20 target site in HR1

VirusCoreceptoraHR1bIC50(μg/ml)Mean IC50c(μg/ml)SDChanged
NL-FLV3R5DIV0.4430.4210.020.0
NFN-SMR5DIV0.397
NFN-SPR5DIV0.423
NL4.3X4DIV0.1200.1250.01−0.5
NL(Stu)XbaX4DIV0.130
MX-FLV3R5GIV0.0560.0320.01−1.1
NFN-SXR5GIV0.047
NLHX SF2 V3R5GIV0.025
NLHX ADA V3BR5GIV0.019
NLHX ADA V3R5GIV0.024
NLHX SF162 V3R5GIV0.032
NFN-MXX4GIV0.0080.0070.00−1.8
NLHXX4GIV0.005
  • a Coreceptor specificity of each chimeric virus.

  • b Amino acids 36 to 38 in the gp41 N-terminal heptad repeat that comprise a critical T-20 target site.

  • c Calculated for chimeric viruses grouped by coreceptor specificity and T-20 target site.

  • d Independent effects of coreceptor specificity and T-20 target site represented on a log10 scale using group mean IC50s.