Table 3.

Quantitation of latent virus from both naive and memory resting T lymphocytes in patients on HAARTa

Patient no.Time on HAART (mo)Plasma HIV-1 RNA (copies/ml)Frequency of latently infected CD4+ T cells (IUPM)Purityb (%)
CD45RA+CD45RO+CD45RA+CD45RO+
929.8 N.D.c 1.1<1.699.899.4
35.9<500.090.5N.D.N.D.
1041.0129<0.45.098.698.3
1129.2<500.13.099.799.2
2134.01413.08.099.799.5
5024.8<50<0.21.199.498.8
  • a Patients studied had been on long-term HAART with suppression of plasma HIV-1 RNA to below 200 copies/ml.

  • b Purity refers to the percentage of CD4+ HLA-DR cells in the sorted population and was calculated as (1−[number of CD4+HLA-DR+ cells/number of CD4+HLA-DR cells]) × 100.

  • c N.D., not done.