Table 2.

Gag-specific CTL responses in the Durban cohorts studied

Best-recognized peptideSubjectaHLA class I typeCTL (per one million PBMCs)Defined dominant epitope [HLA restriction]
p17c.4RCC-001A3/23 B49/5802 Cw6/-1,000RLRPGGKKK [A3]
RCC-002A*3001/66 B42/81 Cw4/17>1,000RLRPGGKKHYMIKHLVW [NDb]
338-MA2/69 B7/42 Cw7/17>1,000RLRPGGKKHYMIKHLVW [ND]
KEH04-MA30/- B42/72 Cw2/17354RLRPGGKKHYMIKHLVW [ND]
p17c.7RCC-006A6801/- B62/71 Cw-/-600LVWASRELERFALNPGL [ND]
RCC-007ND1,000LVWASRELERFALNPGL [ND]
p17c.11338-MA2/69 B7/42 Cw7/17>1,000IIKQLQPALQTGTEEL [ND]
p17c.13338-MA2/69 B7/42 Cw7/17>1,000SLYNTVATL [A2]
325-MA3/30 B*5802/72 Cw2/6>1,000ELRSLYNTVATLYCV [ND]
200-MND1,500ELRSLYNTVATLYCV [ND]
KEH18-MA*6802/- B44/*5802 Cw4/6320ELRSLYNTVATLYCV [ND]
p24c.3994-MA3/74 B57/62 Cw04/-760NAWVKVIEEKAFSPEVIPF [ND]
p24.51020-C5YA2/*3002 B14/*5802 Cw6/8640TPQDLNTML [ND]
1023-C6WA24/30 B8/72 Cw2/7540TPQDLNTML [ND]
021-MA1/34 B72/81 Cw2/18>1,000SALSEGATPQDLNTMLNTVG [ND]
023-MA29/3002 B7/42 Cw7/17>1,000SALSEGATPQDLNTMLNTVG [ND]
252-MA29/*6802 B18/*5802 Cw5/6>1,000SALSEGATPQDLNTMLNTVG [ND]
270-MA23/*6802 B41/71 Cw3/17>1,000SALSEGATPQDLNTMLNTVG [ND]
272-MA30/34 B*5802/81 Cw6/18>1,000SALSEGATPQDLNTMLNTVG [ND]
298-MA1/*6801 B*5802/81 Cw6/18>1,500SALSEGATPQDLNTMLNTVG [ND]
982-MND>1,000TPQDLNTML [ND]
987-MA2/*3002 B*5801/81 Cw04/->1,000TPQDLNTML [ND]
991-MA1/*3002 B8/81 Cw7/18980TPQDLNTML [ND]
1023-MA2/24 B8/*5802 Cw6/7>1,000SALSEGATPQDLNTMLNTVG [ND]
1031-MND>1,000TPQDLNTML [ND]
KEH01-MA30/68 B14/42 Cw8/17380SALSEGATPQDLNTMLNTVG [ND]
KEH02-MA30/- B42/72 Cw2/17900SALSEGATPQDLNTMLNTVG [ND]
KEH19-MA*3002/66 B42/*5802 Cw6/17920TPQDLNTML [B42]
p24c.16RC-005ND520NPPIPVDIYKRWII [ND]
973-MA1/3 B8/- Cw7/-1,860DIYKRWII [B8]
p24c.171020-MA2/- B*5802/62 Cw4/6900GLNKIVRMY [ND]
p24c.20RCC-007ND1,000SILDIKQGPKEPFRDY [ND]
109-MA2/23 B72/- Cw2/-420SILDIKQGPKEPFRDY [ND]
188-MA2/*6801 B18/*5802 Cw5/6720SILDIKQGPKEPFRDY [ND]
260-MND173SILDIKQGPKEPFRDY [ND]
p24c.22RCC-004A23/69 B-/- Cw3/18>1,000FRDYVDRFFKTLRAEQA [ND]
022-MA*3001/*3002 B42/45 Cw3/17380FRDYVDRFFKTLRAEQA [ND]
270-MA23/*6802 B41/71 Cw3/17>1,000FRDYVDRFFKTLRAEQA [ND]
971-MA26/68 B8/71 Cw3/71,080FRDYVDRFFKTLRAEQA [ND]
1011-MA*6802/74 B71/- Cw3/4840FRDYVDRFFKTLRAEQA [ND]
p24c.24RCC-004A23/69 B-/- Cw3/18>1,000QATQDVKNWMTDTLLV [ND]
p24c.25RC-007ND520WMTDTLLVQNANPDCKTI [ND]
p24c.28KEH14-MA3/33 B71/72 Cw-/-340EEMMTACQGVGGPSHKARVL [ND]
  • a Subjects coded by a number followed by “M” represent adults in the cohort. All subjects were of the African racial group.

  • b ND, not determined.