Mice | Immunization route | Mean anti-NP Ab titer^{b} (log_{2}) | Mean titers^{b} (log_{2}) of neutralizing Ab to influenza virus strain | |
---|---|---|---|---|

A/Udorn (H3N2) | A/PR/8/34 (H1N1) | |||

IFN-γ^{+/+}
| No virus | 10.96 | <3 | <3 |

IFN-γ^{+/+}
| i.v. | 18.52 ± 0.72 | 9.35 ± 0.22 | <5 |

IFN-γ^{+/+}
| TRT | 19.56 ± 0.54 | 9.30 ± 0.59^{c}
| <5 |

IFN-γ^{−/−}
| TRT | 18.16 ± 0.83 | 8.65 ± 0.45^{d}
| <5 |

↵a IFN-γ

^{−/−}and immunocompetent (IFN-γ^{+/+}) BALB/c mice were immunized by i.v. or TRT exposure with 5 × 10^{5}PFU of influenza virus A/Udorn (H3N2) per mouse. Four weeks later, sera were collected and assayed for levels of Abs.↵b The values represent the means of Ab titers for five mice in each group, and (where shown) SEM.

^{c,d}The two-tailed*P*value is 0.0943, considered not significant.