Table 1.

Antiviral activity of MRL-1237, guanidine hydrochloride, HBB, and enviroxime against enteroviruses

Virus strainAntiviral activity (μM)a
MRL-1237Guanidine hydrochlorideHBBEnviroxime
EC50SIEC50SIEC50SIEC50SI
Mahoney115172024>200<1.90.30170
Sabin 19.55934050>200<1.90.31160
Sabin 22.91903205326150.11450
Sabin 37.080390441702.20.17290
CB3 Nancy0.589702,2007.7705.40.26190
CB4 JVB0.551,0002,1008.1665.80.14360
  • a CC50 values (μM) were as follows: MRL-1237, 560; guanidine hydrochloride, 17,000; HBB, 380; and enviroxime, 50. SI, selective index, measured as the ratio CC50:EC50.