Table 5.

T-cell proliferation after adoptive reconstitution of LCMV carrier mice with spleen cells from LCMV-immune or naivegld mice

ExptReconstitutionaProliferationb
1LCMV-naivegld 222 ± 11
LCMV-immune gld 53 ± 4.4
2None212 ± 17
LCMV-immune C57BL/62.5 ± 15
LCMV-immunegld 141 ± 3.3
3None174 ± 36
LCMV-immune C57BL/62.2 ± 0.1
LCMV-immunegld 179 ± 12
4LCMV-immune C57BL/65.9 ± 2.0
LCMV-immunegld 41 ± 5.1
  • a LCMV carrier mice were reconstituted with 3 × 107 to 4 × 107 of the indicated C57BL/6 or congenic gld mutant spleen cells.

  • b Numbers represent 103 mean cpm ± standard deviation after a 6-h pulse with 1 μCi of [3H]thymidine after 2 days of culture with plate-bound anti-CD3 antibody.