Table 2.

Magnitude and cross-reactivity of neutralizing antibodies detected 8 weeks post-virus challenge

Vaccine group and animal no.aNab titer to SIV ofb:
smH-4E660DeltaB670mac251mac239
MVA-SIV-gag-pol
 A45,788<302,011476<20
 A55,539<301,978343<20
 A614,168<303,713503<20
MVA-SIV-env
 B126,347<301,968162<20
 B511,279<301,599756<20
 B611,546<30506<20<20
MVA-SIV-gag-pol-env
 C129,281<304,127858<20
 C516,3101802,9501,015<20
 C619,422<302,494<20<20
MVA
 D110,633<304,689661<20
 D23,206<301,118345<20
 D47,405<302,465337<20
  • a Plasma samples from three animals in each of four immunization groups were obtained 8 weeks post-intravenous challenge with SIVsmE660.

  • b Plasma samples were assessed for antibodies neutralizing SIVsmH-4, SIVsmE660, SIV/DeltaB670, SIVmac251, and molecularly cloned SIVmac239 in CEMx174 cells as described in the text. Titers of neutralizing antibodies are the reciprocal plasma dilution at which 50% of cells were protected from virus-induced killing.