Table 1.

Magnitude and cross-reactivity of neutralizing antibodies detected 2 weeks post-virus challenge

Vaccine group and animal no.aNab titer to SIV ofb:
smH-4DeltaB670mac251
MVA-SIV-gag-pol
 A4<30<20<20
 A542031<20
 A639630<20
MVA-SIV-env
 B128,4782,11645
 B543,6805,947831
 B660,3093,48337
MVA-SIV-gag-pol-env
 C150,0726,034969
 C542,2973,700958
 C648,9382,56148
MVA
 D1<20<20<20
 D2<20<20<20
 D4<20<2044
  • a Plasma samples from three animals in each of four immunization groups were obtained 2 weeks post-intravenous challenge with SIVsmE660.

  • b Plasma samples were assessed for antibodies neutralizing SIVsmH-4, SIV/DeltaB670, and SIVmac251 in CEMx174 cells as described in the text. Titers of neutralizing antibodies are the reciprocal plasma dilution at which 50% of cells were protected from virus-induced killing.