Table 1.

CD4 and CXCR4 expression in cell lines and their sensitivity to HHV-7 infection

Cell line% CD4+cellsa% CXCR4+cellsaSusceptibility to HHV-7 infectionb
MT-2>95>95
MT-4>95>95
SupT1>95>95+
HUT-789042
CEM/X174>9560
HOS.CD4>9029
HOS.CD4.CXCR4>90>90
U87.CD4>95Negative
U87.CD4.CXCR4>9588
  • a The percentages of positive cells were obtained on the basis of the cells stained with control isotype-matched MAb. CD4+ cells were stained with PE-conjugated Leu3a. CXCR4+ cells were stained with MAb 12G5 and GaM-FITC.

  • b HHV-7 infection was evaluated by anti-HHV-7 MAb staining at days 7, 10, and 14 after infection and microscopic evaluation of the cell cultures. −, not infectable; +, HHV-7 infectable.