Table 1.

Comparison of T-lymphocyte subsets and proliferation rates in sooty mangabeys and rhesus macaques

Test condition and concn measuredResults fora:
MangabeysMacaques
SIV negativeSIV positivePSIV negativeSIV positiveP
No. of subjects19201721
 CD4+ T cells/mm3 1618 ± 1561051 ± 1130.00861220 ± 105518 ± 64<0.0001
 CD8+ T cells/mm3 1446 ± 1972156 ± 296NS870 ± 94862 ± 115NS
 % of Ki-67+ CD4+cells3.5 ± 0.24.2 ± 0.4NS7.0 ± 0.512.0 ± 1.10.0003
 % of Ki-67+ CD8+cells3.6 ± 0.34.2 ± 0.3NS7.8 ± 0.919.0 ± 2.7<0.0001
 Ki-67+ CD4+cells/mm3 54.4 ± 5.141.5 ± 6.1NS99.0 ± 14.656.9 ± 8.00.0091
 Ki-67+ CD8+cells/mm3 57.2 ± 12.492.0 ± 14.70.025569.7 ± 11.1165.2 ± 33.00.0100
No. of subjects17172021
 % of CD45RA+ CD4+cells22.8 ± 2.920.8 ± 2.9NS52.4 ± 4.365.6 ± 3.90.02
 % of CD45RA+ CD8+cells50.4 ± 3.445.9 ± 3.8NS73.7 ± 3.366.1 ± 2.54NS
No. of subjects25242523
 % of CD3+PBMC66.50 ± 1.470.27 ± 1.9NS64.13 ± 1.944.89 ± 2.6<0.0001
  • a Data are means ± standard errors of the means. The statistical comparisons were done with the Mann-Whitney U test. NS, not significant.