TABLE 2

Neutralizing antibody ID50 titers of rhesus sera against the wild-type and mutant clonesa

TierCloneID50 titer
4 wk postinfection40 wk postinfection80 wk postinfection
1wt28,900211,0001,360,000
ΔCT<20651,540
2wt<20380406
ΔCT<20<201,870
3wt<20<20568
ΔCT<20<204,920
  • a ID50 titers were calculated with nonlinear regression by using PRISM5 and are expressed as the highest dilution of sera that resulted in a 50% reduction of RLU compared with the virus control. The sera used were collected at 4 weeks, 40 weeks, and 80 weeks postinfection from a rhesus macaque infected with the SIVsmE660 tier 1 virus. wt, wild type.