TABLE 1

Amino acid sequence polymorphism around the VNDT motif in ZIKV isolates

TypePolymorphism(s)Sequence (148–162)aNo. with polymorphism/total
AfricanAsianAmerican
IΔVNDTHSGMI....GHETDE5/610/410/228
IIΔIVNDT, ΔTGHETD, ΔTGHETDEHSGM........TDE8/611/410/228
IIIVNDIHSGMIVNDIGHETDE24/612/410/228
IVVNDTHSGMIVNDTGHETDE24/6138/41184/228b
  • a Of the total number of sequences (n = 330) examined, 264 were from full-length genomes and 66 from partial E-coding sequences currently available in GenBank. The African sequences represented 17 full-length genomes and 44 partial E sequences; Asian sequences represented 32 full-length genomes and 9 partial E sequences; American sequences represented 215 full-length genomes and 13 partial E sequences. Amino acid sequences from 148 to 162 of E are shown. VNDT is in bold-face with the glycosylation site underlined. The periods represent sequence not present in the isolates.

  • b Forty-four sequences from the American isolates had incomplete sequence information.