Table 4.

Virus isolation from PBMC of rhesus macaques inoculated once with SHIV 89.6-PDa

AnimalRoute of inoculationVirus dose (TCID50)Isolation of virus at the indicated wk p.i.b
123468121620242832364044
19854i.v.25,000+++++++++c
20458i.v.25,000+++++++++++c
25757IVAGd 25,000+++++++++++++++
25788IVAG25,000++++++++++c
26904IVAG25,000++++++++++++++
25772IVAG25,000e
26428IVAG25,000+++++++++++++++
25902IVAG25,000+++++++++c
26261IVAG2,500
26814IVAG2,500+++++++++c
  • a All virus inoculations consisted of 1 ml of virus stock, and all inoculations summarized in this table were done without addition of seminal plasma.

  • b +, virus isolated; −, no virus isolated.

  • c Results of virus isolation from PBMC at the time of necropsy. Animals were necropsied due to severe clinical signs of AIDS.

  • d IVAG, intravaginal.

  • e This animal was reinoculated intravaginally with 1 ml of undiluted SHIV 89.6-PD at this time.