TABLE 1.

Inhibition of visna virus replication by PD98059a

Treatment% Virus replication
SCPGSM
None100100
DMSO56.4 ± 3.583.0 ± 30.0
PD98059b18.8 ± 7.14.7 ± 0.9
  • a Virus replication was assessed by measuring RT activity (in counts per minute per milliliter) in supernatants of infected SCP or GSM cells treated or not with DMSO or PD98059. Treatments were added 1 h prior to infection and maintained in the media throughout the experiment. Supernatants were collected after 5 to 7 days of infection. Data are expressed as a percentage of the infected, untreated samples. Data for treated samples are means ± standard deviations.

  • b SCP cells were treated with 50 μM PD98059 and GSM cells were treated with 25 μM PD98059.