TABLE 7.

Pathogenicity of goose H5N1 influenza virus isolates in micea

Virus strainNo. of mice dead/totalbDisease signsMean virus titer (log10 EID50 ± SE)c in:
Lung on day:Brain on day 3
37
Gs/HK/437-4/994/8+3.2 ± 0.21.5 ± 0.1<0.1
Gs/HK/437-6/990/104.2 ± 0.22.5 ± 0.6<0.1
Gs/HK/437-8/994/8+2.8 ± 0.22.8 ± 0.4<0.1
Gs/HK/437-10/994/8+2.3 ± 0.20.8 ± 0.5<0.1
Gs/HK/485-3/004/10+2.5 ± 01.5 ± 0.5<0.1
Gs/HK/485-5/008/10+3.2 ± 0.41.7 ± 0.70.3 ± 0.1
  • a Each anesthetized mouse was intranasally inoculated with 106.5 or 106.75 EID50 of virus in a volume of 0.1 ml.

  • b Determined during a period that ended 16 days after infection.

  • c Whole brains and lungs were homogenized and resuspended in 1.0 ml of PBS before the virus titers were determined. The data were recorded for the tissues of three mice per group.