TABLE 2.

Data for individual animals

Animal IDSexAge (yr)Inoculum size (105 TCID50)Day p.i.Histopathological findings
AA16F31.03Indistinguishable from uninfected animals
AVFM44.15Axillary LN: focal expansion and distortion of germinal centers
Thymus: within normal limits
Duodenum: prominent germinal centers in the GALT
AE50F31.07Mesenteric LN: lymphoid hyperplasia with focal expansion of paracortex
Cecum: diffuse and moderate hyperplasia of the GALT
Thymus: within normal limits
AH5EF31.010Mesenteric, colonic LN: lymphoid hyperplasia with numerous large active germinal centers
Duodenum, jejunum, ileum: hyperplasia of the GALT
Thymus: within normal limits
AE56F31.014Mesenteric LN: lymphoid hyperplasia with numerous cortical and paracortical follicles, many with depleted germinal centers
Ileum: hyperplasia of the GALT with prominent active germinal centers
Thymus: mild cortical depletion
BD35M23.021Multiple LN: lymphadenopathy with follicular hyperplasia, paracortical expansion, and multifocal neutrophilic infiltrates and erythrophagocytosis
Thymus: mild and diffuse cortical lymphoid depletion