Table 1.

Genomic organization of the recombinant Ad vectorsa

VectorVirusExpression cassetteE1E2AE4
AdE1°AdRSVβgalRSV-lacZ Deletedwtb wt
AdE1°AdTG4656MLP-lacZ Deletedwtwt
AdE1°E2A°AdTG9542MLP-lacZ DeletedDeletedwt
AdE1°E4°AdTG8595MLP-lacZ DeletedwtDeleted
AdE1°E4°AdTG5643CMV-CFTRc DeletedwtDeleted
AdE1°AdTG6401Deletedwtwt
AdE1°E2A°AdTG9592DeletedDeletedwt
AdE1°E4°AdTG9546DeletedwtDeleted
AdE1+E4°AdTG9572wtwtDeleted
  • a All vectors contain a deletion (nt 28592 to 30480) in the viral E3 region.

  • b wt, wild type.

  • c CFTR, cystic fibrosis transmembrane conductance regulator.