Table 1.

HIV-1 isolates and clones used in this studya

VirusTropismbClonalitycReplication in:SourceReference
U87MG-CD4-CCR5 cellsU87MG-CD4-CXCR4 cells
CCR5 primary
 SF162NSIIsolateC. Cheng-Mayer 86
 JR-FLNSIBiol. clone+I. S. Y. Chen 71
 Case B2-6-92NSIIsolate+/−R. I. Connor 18
 ADA (clAD8)NSIMol. clone+M. A. Martin 93
CCR5 + CXCR4 primary
 Isolate C7/86SIIsolate+++++R. I. Connor 18
 DH123SIMol. clone++++R. Shibata 85
 2076 cl1SIBiol. clone++++P. R. Clapham 89
 2076 cl3SIBiol. clone++++P. R. Clapham 89
 P17SIIsolate+++++R. A. Fisher 97
 Case B5/86SIIsolate+/−++R. I. Connor 18
 89.6SIMol. clone+++R. G. Collman 16
CXCR4 primary
 HC4SIBiol. clone (p)+++S. E. Forte 34
 HC7SIBiol. clone (p)+++S. E. Forte 34
 2075SIIsolate+++P. R. Clapham 89
 2044SIIsolate++P. R. Clapham 89
 2005 cl1SIBiol. clone+/−P. R. Clapham 89
 ACH-PSIIsolate+/−+++T. Wrin 102
CCR5 + CXCR4 TCLA
 SF2SIMol. clone+++C. Cheng Mayer 86
 P17/H9SIIsolate++++++A. Trkola and R. A. Fisher 97
 C17SIIsolate+++++R. A. Fisher 97
CXCR4 TCLA
 NL4-3SIMol. clone+++W. O’Brien 1
 ACH-H9SIIsolate+/−+++T. Wrin 102
 ACH-p/H9SIIsolate++++T. Wrin 102
  • a Grouped according to coreceptor usage pattern.

  • b As judged by syncytium formation in MT-2 cells.

  • c Whether virus is an uncloned isolate, a biological (biol.) clone, or a molecular (mol.) clone and whether it was of pediatric origin (p).