Table 3.

Neutralization of dualtropic HIV-1 isolates in U87MG-CD4 cells

VirusID50(μg/ml)a
2F52G12sCD4CD4-IgG215eIgG1b1219b447-52D
CCR5CXCR4CCR5CXCR4CCR5CXCR4CCR5CXCR4CCR5CXCR4CCR5CXCR4CCR5CXCR4CCR5CXCR4
SF29.64.814.125.67.814.61.270.84>507.7NDND>50>500.860.22
Isolate C7/8635.6>506.3413.38.0224.46.84.71>50>503.41.4>50>5034.734.3
DH123640.38.8>5020.317.5<0.42.9>50>501.92.6>50>50NDND
2076 cl314.223.20.996.12>50>502325.8>50>50NDNDNBNBNDND
P17>50>50>50>508.725.80.910.78>50>50NDNDNBNBNDND
P17/H9>50>508.417.210.53.90.620.62>50>501.79.0NBNB>50>50
C1717.517.1>5034.88.694.82.671.9>50>50NDNDNBNBNDND
  • a Derived from one representative experiment out of two to five performed. When no neutralization at 50 μg/ml was observed, a value >50 μg/ml is reported. For each neutralizing agent, ID50 values obtained on the CCR5-expressing (CCR5) and the CXCR4-expressing (CXCR4) U87MG-CD4 cells are shown. ND, not done; NB, no binding.