TABLE 1

Interferon-stimulated genes

GeneaRelative expression in:
SIVmac239-infected vs Δ5G-infected animalsSIVmac239-infected vs uninfected animalsΔ5G-infected vs uninfected animals
Fold changebP valueFold changeP valueFold changeP value
IFNB12.842.26E−02
IFITM34.463.13E−063.381.06E−04
STAT15.652.64E−053.662.38E−06
RSAD22.822.23E−0269.071.71E−0724.521.39E−05
MX12.001.57E−0218.904.14E−079.472.84E−07
IFI351.424.15E−033.559.39E−102.505.44E−07
IFI61.642.34E−0324.735.20E−0915.076.37E−08
IRF71.585.27E−0312.591.73E−087.963.43E−07
MX21.843.20E−039.372.34E−095.101.17E−06
OASL3.581.97E−0522.521.78E−096.301.76E−06
IFI272.167.67E−0333.073.36E−0615.338.00E−05
ISG151.725.97E−0347.912.81E−0927.841.28E−08
OAS22.032.85E−0410.798.13E−105.313.74E−08
IFIT13.252.89E−0347.555.47E−0614.614.22E−05
IFIT32.774.39E−0335.643.44E−0612.851.41E−05
ISG201.736.55E−054.074.70E−082.351.45E−05
OAS12.886.31E−0443.294.48E−0915.033.08E−07
GBP22.881.42E−046.949.79E−072.419.13E−05
GBP13.133.46E−0513.843.78E−074.425.40E−05
GBP64.263.47E−062.571.24E−04
IFIT55.667.60E−054.098.76E−06
IFIT21.983.67E−0220.932.37E−0610.561.41E−06
STAT23.381.20E−052.788.45E−04
IFI44L2.454.62E−0228.053.26E−0511.461.41E−03
Avg2.3520.709.11
  • a All genes with the exception of IFNB1 belonged to group 3 as determined by hierarchical clustering analyses of transcriptome analysis data (Fig. 2B). IFNB1 belonged to group 5.

  • b Fold changes between two groups with statistically significant differences (P < 0.05) are shown.