PT  - JOURNAL ARTICLE
AU  - Veazey, Ronald S.
AU  - Mansfield, Keith G.
AU  - Tham, Irene C.
AU  - Carville, Angela C.
AU  - Shvetz, Daniel E.
AU  - Forand, Amy E.
AU  - Lackner, Andrew A.
TI  - Dynamics of CCR5 Expression by CD4<sup>+</sup> T Cells in Lymphoid Tissues during Simian Immunodeficiency Virus Infection
AID  - 10.1128/JVI.74.23.11001-11007.2000
DP  - 2000 Dec 01
TA  - Journal of Virology
PG  - 11001--11007
VI  - 74
IP  - 23
4099  - http://jvi.asm.org/content/74/23/11001.short
4100  - http://jvi.asm.org/content/74/23/11001.full
SO  - J. Virol.2000 Dec 01; 74
AB  - Early viral replication and profound CD4+ T-cell depletion occur preferentially in intestinal tissues of macaques infected with simian immunodeficiency virus (SIV). Here we show that a much higher percentage of CD4+ T cells in the intestine express CCR5 compared with those found in the peripheral blood, spleen, or lymph nodes. In addition, the selectivity and extent of the CD4+ T-cell loss in SIV infection may depend upon these cells coexpressing CCR5 and having a “memory” phenotype (CD45RA−). Following intravenous infection with SIVmac251, memory CD4+ CCR5+ T cells were selectively eliminated within 14 days in all major lymphoid tissues (intestine, spleen, and lymph nodes). However, the effect on CD4+T-cell numbers was most profound in the intestine, where cells of this phenotype predominate. The CD4+ T cells that remain after 14 days of infection lacked CCR5 and/or were naive (CD45RA+). Furthermore, when animals in the terminal stages of SIV infection (with AIDS) were examined, virtually no CCR5-expressing CD4+ T cells were found in lymphoid tissues, and all of the remaining CD4+ T cells were naive and coexpressed CXCR4. These findings suggest that chemokine receptor usage determines which cells are targeted for SIV infection and elimination in vivo.