COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

Juan García-Arriaza; Urtzi Garaigorta; Patricia Pérez; Adrián Lázaro-Frías; Carmen Zamora; Pablo Gastaminza; Carlos Del Fresno; José M. Casasnovas; Carlos Óscar S. Sorzano; David Sancho; Mariano Esteban

doi:10.1128/JVI.02260-20

Vaccines and Antiviral Agents

COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

Juan García-Arriaza, Urtzi Garaigorta, Patricia Pérez, Adrián Lázaro-Frías, Carmen Zamora, Pablo Gastaminza, Carlos Del Fresno, José M. Casasnovas, Carlos Óscar S. Sorzano, David Sancho, Mariano Esteban

Juan García-Arriaza

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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For correspondence: mesteban@cnb.csic.es jfgarcia@cnb.csic.es

Urtzi Garaigorta

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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Patricia Pérez

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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Adrián Lázaro-Frías

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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Carmen Zamora

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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Pablo Gastaminza

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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Carlos Del Fresno

bLaboratory of Immunobiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain;

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José M. Casasnovas

cDepartment of Macromolecular Structures, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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Carlos Óscar S. Sorzano

dBiocomputing Unit, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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David Sancho

bLaboratory of Immunobiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain;

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Mariano Esteban

aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

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For correspondence: mesteban@cnb.csic.es jfgarcia@cnb.csic.es

DOI: 10.1128/JVI.02260-20

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DOI

https://doi.org/10.1128/JVI.02260-20

PubMed

33414159

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American Society for Microbiology Journals

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Published online January 7, 2021.

Author Information

Juan García-Arriazaa *,
Urtzi Garaigortaa,
Patricia Péreza,
Adrián Lázaro-Fríasa,
Carmen Zamoraa,
Pablo Gastaminzaa,
Carlos Del Fresnob,
José M. Casasnovasc,
Carlos Óscar S. Sorzanod,
David Sanchob and
Mariano Estebana *

^aDepartment of Molecular and Cellular Biology, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;
^bLaboratory of Immunobiology, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 28029 Madrid, Spain;
^cDepartment of Macromolecular Structures, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;
^dBiocomputing Unit, Centro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), 28049 Madrid, Spain;

↵*Address correspondence to Mariano Esteban (mesteban{at}cnb.csic.es) and Juan García-Arriaza (jfgarcia{at}cnb.csic.es)

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COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice

Journal of Virology Jan 2021, JVI.02260-20; DOI: 10.1128/JVI.02260-20

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COVID-19 vaccine candidates based on modified vaccinia virus Ankara expressing the SARS-CoV-2 spike induce robust T- and B-cell immune responses and full efficacy in mice