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Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage

Kun Xu, Yufeng Song, Lianpan Dai, Yongli Zhang, Xuancheng Lu, Yijia Xie, Hangjie Zhang, Tao Cheng, Qihui Wang, Qingrui Huang, Yuhai Bi, William J. Liu, Wenjun Liu, Xiangdong Li, Chuan Qin, Yi Shi, Jinghua Yan, Dongming Zhou, George F. Gao
Kun Xu
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, Chinaa
University of Chinese Academy of Sciences, Beijing 101408, Chinab
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Yufeng Song
Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, Chinac
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Lianpan Dai
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, Chinaa
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Yongli Zhang
College of Laboratory Medicine and Life Sciences, Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325035, Chinad
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Xuancheng Lu
Laboratory Animal Center, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, Chinae
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Yijia Xie
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, Chinaa
University of Chinese Academy of Sciences, Beijing 101408, Chinab
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Hangjie Zhang
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, Chinaf
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Tao Cheng
Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, Chinac
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Qihui Wang
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Chinag
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Qingrui Huang
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Chinag
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Yuhai Bi
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, Chinah
Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, Chinai
Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, Chinaj
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William J. Liu
College of Laboratory Medicine and Life Sciences, Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325035, Chinad
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, Chinaf
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Wenjun Liu
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, Chinah
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Xiangdong Li
State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, Chinak
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Chuan Qin
Comparative Medicine Centre, Peking Union Medical College (PUMC) and Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Beijing, Chinal
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Yi Shi
University of Chinese Academy of Sciences, Beijing 101408, Chinab
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, Chinah
Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, Chinai
Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, Chinaj
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Jinghua Yan
University of Chinese Academy of Sciences, Beijing 101408, Chinab
CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Chinag
Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, Chinai
Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, Chinaj
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Dongming Zhou
Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, Chinac
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  • For correspondence: gaof@im.ac.cn dmzhou@sibs.ac.cn
George F. Gao
Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, Chinaa
University of Chinese Academy of Sciences, Beijing 101408, Chinab
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, Chinaf
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, Chinah
Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, Chinai
Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, Chinaj
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, Chinam
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  • For correspondence: gaof@im.ac.cn dmzhou@sibs.ac.cn
DOI: 10.1128/JVI.01722-17
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Article Information

DOI 
https://doi.org/10.1128/JVI.01722-17
PubMed 
29298885

Published By 
American Society for Microbiology Journals
History 
  • Published online January 3, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.

Article Versions

  • You are currently viewing an Accepted Manuscript version of this article (January 03, 2018).
  • View the most recent version of this article

Author Information

  1. Kun Xua,b,
  2. Yufeng Songc,
  3. Lianpan Daia,
  4. Yongli Zhangd,
  5. Xuancheng Lue,
  6. Yijia Xiea,b,
  7. Hangjie Zhangf,
  8. Tao Chengc,
  9. Qihui Wangg,
  10. Qingrui Huangg,
  11. Yuhai Bih,i,j,
  12. William J. Liud,f,
  13. Wenjun Liuh,
  14. Xiangdong Lik,
  15. Chuan Qinl,
  16. Yi Shib,h,i,j,
  17. Jinghua Yanb,g,i,j,
  18. Dongming Zhouc# and
  19. George F. Gaoa,b,f,h,i,j,m#
  1. Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, Chinaa
  2. University of Chinese Academy of Sciences, Beijing 101408, Chinab
  3. Vaccine Research Center, Key Laboratory of Molecular Virology & Immunology, Institute Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, Chinac
  4. College of Laboratory Medicine and Life Sciences, Institute of Medical Virology, Wenzhou Medical University, Wenzhou 325035, Chinad
  5. Laboratory Animal Center, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, Chinae
  6. National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention (China CDC), Beijing 102206, Chinaf
  7. CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, Chinag
  8. CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100071, Chinah
  9. Center for Influenza Research and Early-Warning (CASCIRE), Chinese Academy of Sciences, Beijing 100101, Chinai
  10. Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People's Hospital, Shenzhen 518112, Chinaj
  11. State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, Chinak
  12. Comparative Medicine Centre, Peking Union Medical College (PUMC) and Institute of Laboratory Animal Sciences, Chinese Academy of Medical Sciences (CAMS), Beijing, Chinal
  13. Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, Chinam

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Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage
Kun Xu, Yufeng Song, Lianpan Dai, Yongli Zhang, Xuancheng Lu, Yijia Xie, Hangjie Zhang, Tao Cheng, Qihui Wang, Qingrui Huang, Yuhai Bi, William J. Liu, Wenjun Liu, Xiangdong Li, Chuan Qin, Yi Shi, Jinghua Yan, Dongming Zhou, George F. Gao
Journal of Virology Jan 2018, JVI.01722-17; DOI: 10.1128/JVI.01722-17

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Recombinant Chimpanzee Adenovirus Vaccine AdC7-M/E Protects against Zika Virus Infection and Testis Damage
Kun Xu, Yufeng Song, Lianpan Dai, Yongli Zhang, Xuancheng Lu, Yijia Xie, Hangjie Zhang, Tao Cheng, Qihui Wang, Qingrui Huang, Yuhai Bi, William J. Liu, Wenjun Liu, Xiangdong Li, Chuan Qin, Yi Shi, Jinghua Yan, Dongming Zhou, George F. Gao
Journal of Virology Jan 2018, JVI.01722-17; DOI: 10.1128/JVI.01722-17
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