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Cellular Response to Infection

Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity

Eunok Lee, Kerrie Sandgren, Gabriel Duette, Vicki V. Stylianou, Rajiv Khanna, John-Sebastian Eden, Emily Blyth, David Gottlieb, Anthony L. Cunningham, Sarah Palmer
Kanta Subbarao, Editor
Eunok Lee
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
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  • ORCID record for Eunok Lee
Kerrie Sandgren
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
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Gabriel Duette
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
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Vicki V. Stylianou
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
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Rajiv Khanna
cFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia
dQIMR Berghofer Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
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John-Sebastian Eden
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
eCentre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
fMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Westmead, New South Wales, Australia
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Emily Blyth
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
gCentre for Cancer Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
hBMT and Cell Therapies Program, Westmead Hospital, Westmead, New South Wales, Australia
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David Gottlieb
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
gCentre for Cancer Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
hBMT and Cell Therapies Program, Westmead Hospital, Westmead, New South Wales, Australia
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Anthony L. Cunningham
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
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Sarah Palmer
aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
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Kanta Subbarao
The Peter Doherty Institute for Infection and Immunity
Roles: Editor
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DOI: 10.1128/JVI.02002-20
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Article Information

DOI 
https://doi.org/10.1128/JVI.02002-20
PubMed 
33443088

Published By 
American Society for Microbiology Journals
History 
  • Received October 11, 2020
  • Accepted December 16, 2020
  • Published online February 24, 2021.

Copyright & Usage 
Copyright © 2021 Lee et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.
Editors and / or Reviewers 
  • Kanta Subbarao, Editor, The Peter Doherty Institute for Infection and Immunity

Article Versions

  • Accepted Manuscript version (December 21, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Eunok Leea,b,
  2. Kerrie Sandgrena,b,
  3. Gabriel Duettea,b,
  4. Vicki V. Stylianoua,b,
  5. Rajiv Khannac,d,
  6. John-Sebastian Edena,b,e,f,
  7. Emily Blythb,g,h,
  8. David Gottliebb,g,h,
  9. Anthony L. Cunninghama,b and
  10. Sarah Palmera,b
  1. aCentre for Virus Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
  2. bSydney Medical School, Faculty of Medicine and Health, The University of Sydney, Camperdown, New South Wales, Australia
  3. cFaculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia
  4. dQIMR Berghofer Centre for Immunotherapy and Vaccine Development, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia
  5. eCentre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
  6. fMarie Bashir Institute for Infectious Diseases and Biosecurity, School of Life and Environmental Sciences and School of Medical Sciences, The University of Sydney, Westmead, New South Wales, Australia
  7. gCentre for Cancer Research, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia
  8. hBMT and Cell Therapies Program, Westmead Hospital, Westmead, New South Wales, Australia
  • Address correspondence to Eunok Lee, eunok.lee{at}sydney.edu.au.
  • Eunok Lee, Kerrie Sandgren, and Gabriel Duette contributed equally to this article. Author order was determined by the contribution to the results presented in the manuscript and contribution to writing the initial manuscript draft. Anthony L. Cunningham and Sarah Palmer are co-senior authors with equal contributions.

  • Citation Lee E, Sandgren K, Duette G, Stylianou VV, Khanna R, Eden J-S, Blyth E, Gottlieb D, Cunningham AL, Palmer S. 2021. Identification of SARS-CoV-2 nucleocapsid and spike T-cell epitopes for assessing T-cell immunity. J Virol 95:e02002-20. https://doi.org/10.1128/JVI.02002-20.

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Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity
Eunok Lee, Kerrie Sandgren, Gabriel Duette, Vicki V. Stylianou, Rajiv Khanna, John-Sebastian Eden, Emily Blyth, David Gottlieb, Anthony L. Cunningham, Sarah Palmer
Journal of Virology Feb 2021, 95 (6) e02002-20; DOI: 10.1128/JVI.02002-20

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Identification of SARS-CoV-2 Nucleocapsid and Spike T-Cell Epitopes for Assessing T-Cell Immunity
Eunok Lee, Kerrie Sandgren, Gabriel Duette, Vicki V. Stylianou, Rajiv Khanna, John-Sebastian Eden, Emily Blyth, David Gottlieb, Anthony L. Cunningham, Sarah Palmer
Journal of Virology Feb 2021, 95 (6) e02002-20; DOI: 10.1128/JVI.02002-20
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KEYWORDS

COVID-19 vaccines
diagnostic tools
nucleocapsid and spike proteins
protein network
SARS-CoV-2
T-cell effector/polyfunctionality
highly networked/conserved T-cell epitope derived peptides

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