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Pathogenesis and Immunity

Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation

Dani Vézina, Shang Yu Gong, William D. Tolbert, Shilei Ding, Dung Nguyen, Jonathan Richard, Gabrielle Gendron-Lepage, Bruno Melillo, Amos B. Smith III, Marzena Pazgier, Andrés Finzi
Guido Silvestri, Editor
Dani Vézina
aCentre de Recherche du CHUM, Montreal, Quebec, Canada
bDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada
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  • ORCID record for Dani Vézina
Shang Yu Gong
aCentre de Recherche du CHUM, Montreal, Quebec, Canada
cDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
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William D. Tolbert
dInfectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Shilei Ding
aCentre de Recherche du CHUM, Montreal, Quebec, Canada
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Dung Nguyen
dInfectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Jonathan Richard
aCentre de Recherche du CHUM, Montreal, Quebec, Canada
bDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada
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Gabrielle Gendron-Lepage
aCentre de Recherche du CHUM, Montreal, Quebec, Canada
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Bruno Melillo
eDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Amos B. Smith III
eDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Marzena Pazgier
dInfectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
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Andrés Finzi
aCentre de Recherche du CHUM, Montreal, Quebec, Canada
bDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada
cDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
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Guido Silvestri
Emory University
Roles: Editor
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DOI: 10.1128/JVI.01620-20
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Article Information

DOI 
https://doi.org/10.1128/JVI.01620-20
PubMed 
33298541

Published By 
American Society for Microbiology Journals
History 
  • Received August 11, 2020
  • Accepted December 3, 2020
  • Published online February 10, 2021.

Copyright & Usage 
Copyright © 2021 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • Guido Silvestri, Editor, Emory University

Article Versions

  • Accepted Manuscript version (December 09, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Dani Vézinaa,b,
  2. Shang Yu Gonga,c,
  3. William D. Tolbertd,
  4. Shilei Dinga,
  5. Dung Nguyend,
  6. Jonathan Richarda,b,
  7. Gabrielle Gendron-Lepagea,
  8. Bruno Melilloe,
  9. Amos B. Smith IIIe,
  10. Marzena Pazgierd and
  11. Andrés Finzia,b,c
  1. aCentre de Recherche du CHUM, Montreal, Quebec, Canada
  2. bDépartement de Microbiologie, Infectiologie et Immunologie, Université de Montréal, Montreal, Quebec, Canada
  3. cDepartment of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada
  4. dInfectious Diseases Division, Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
  5. eDepartment of Chemistry, School of Arts and Sciences, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  • Address correspondence to Andrés Finzi, andres.finzi{at}umontreal.ca.
  • Citation Vézina D, Gong SY, Tolbert WD, Ding S, Nguyen D, Richard J, Gendron-Lepage G, Melillo B, Smith AB, III, Pazgier M, Finzi A. 2021. Stabilizing the HIV-1 envelope glycoprotein State 2A conformation. J Virol 95:e01620-20. https://doi.org/10.1128/JVI.01620-20.

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Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation
Dani Vézina, Shang Yu Gong, William D. Tolbert, Shilei Ding, Dung Nguyen, Jonathan Richard, Gabrielle Gendron-Lepage, Bruno Melillo, Amos B. Smith III, Marzena Pazgier, Andrés Finzi
Journal of Virology Feb 2021, 95 (5) e01620-20; DOI: 10.1128/JVI.01620-20

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Stabilizing the HIV-1 Envelope Glycoprotein State 2A Conformation
Dani Vézina, Shang Yu Gong, William D. Tolbert, Shilei Ding, Dung Nguyen, Jonathan Richard, Gabrielle Gendron-Lepage, Bruno Melillo, Amos B. Smith III, Marzena Pazgier, Andrés Finzi
Journal of Virology Feb 2021, 95 (5) e01620-20; DOI: 10.1128/JVI.01620-20
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KEYWORDS

HIV-1
envelope glycoproteins
Env conformation
State 2A
nonneutralizing antibodies
CD4-induced antibodies
cluster A
coreceptor binding site
gp120
small CD4 mimetics
soluble CD4

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