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Genetic Diversity and Evolution

Characterization of a Novel Alphaherpesvirus Isolated from the Fruit Bat Pteropus lylei in Vietnam

Takuya Inagaki, Souichi Yamada, Hikaru Fujii, Tomoki Yoshikawa, Miho Shibamura, Shizuko Harada, Shuetsu Fukushi, Mai Quynh Le, Co Thach Nguyen, Thi Thu Thuy Nguyen, Thanh Thuy Nguyen, Thanh Thuy Nguyen, Van Tay Quach, Vu Dinh Thong, Kazuki Mori, Michihito Sasaki, Agus Setiyono, Ekowati Handharyani, Haruko Takeyama, Futoshi Hasebe, Masayuki Saijo
Richard M. Longnecker, Editor
Takuya Inagaki
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
bDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan
cComputational Bio Big-Data Open Innovation Laboratory, AIST-Waseda University, Tokyo, Japan
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Souichi Yamada
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
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Hikaru Fujii
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
dThe Faculty of Veterinary Medicine, Okayama University of Science, Ehime, Japan
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Tomoki Yoshikawa
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
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  • ORCID record for Tomoki Yoshikawa
Miho Shibamura
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
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Shizuko Harada
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
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Shuetsu Fukushi
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
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Mai Quynh Le
eDepartment of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
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Co Thach Nguyen
eDepartment of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
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Thi Thu Thuy Nguyen
eDepartment of Virology, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
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Thanh Thuy Nguyen
fDepartment of Electron Microscopy, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
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Thanh Thuy Nguyen
gBiosafety Department, National Institute of Hygiene and Epidemiology, Hanoi, Vietnam
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Van Tay Quach
hAnimal Health Office of Soc Trang Province, Soc Trang, Vietnam
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Vu Dinh Thong
iDepartment of Zoological Museum, Institute of Ecology and Biological Resources, VAST, Hanoi, Vietnam
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Kazuki Mori
cComputational Bio Big-Data Open Innovation Laboratory, AIST-Waseda University, Tokyo, Japan
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Michihito Sasaki
jDivision of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, Hokkaido, Japan
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Agus Setiyono
kDivision of Veterinary Pathology, Faculty of Veterinary Medicine, IPB University, Bogor, Indonesia
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Ekowati Handharyani
kDivision of Veterinary Pathology, Faculty of Veterinary Medicine, IPB University, Bogor, Indonesia
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Haruko Takeyama
bDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan
cComputational Bio Big-Data Open Innovation Laboratory, AIST-Waseda University, Tokyo, Japan
lInstitute for Advanced Research of Biosystem Dynamics, Waseda University, Tokyo, Japan
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Futoshi Hasebe
mCenter for Infectious Disease Research in Asia and Africa, Vietnam Research Station, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
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Masayuki Saijo
aDepartment of Virology I, National Institute of Infectious Diseases, Tokyo, Japan
bDepartment of Life Science and Medical Bioscience, Waseda University, Tokyo, Japan
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Richard M. Longnecker
Northwestern University
Roles: Editor
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DOI: 10.1128/JVI.00673-20
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ABSTRACT

Herpesviruses exist in nature within each host animal. Ten herpesviruses have been isolated from bats and their biological properties reported. A novel bat alphaherpesvirus, which we propose to name “Pteropus lylei-associated alphaherpesvirus (PLAHV),” was isolated from urine of the fruit bat Pteropus lylei in Vietnam and characterized. The entire genome sequence was determined to be 144,008 bp in length and predicted to include 72 genes. PLAHV was assigned to genus Simplexvirus with other bat alphaherpesviruses isolated from pteropodid bats in Southeast Asia and Africa. The replication capacity of PLAHV in several cells was evaluated in comparison with that of herpes simplex virus 1 (HSV-1). PLAHV replicated better in the bat-originated cell line and less in human embryonic lung fibroblasts than HSV-1 did. PLAHV was serologically related to another bat alphaherpesvirus, Pteropodid alphaherpesvirus 1 (PtAHV1), isolated from a Pteropus hypomelanus-related bat captured in Indonesia, but not with HSV-1. PLAHV caused lethal infection in mice. PLAHV was as susceptible to acyclovir as HSV-1 was. Characterization of this new member of bat alphaherpesviruses, PLAHV, expands the knowledge on bat-associated alphaherpesvirology.

IMPORTANCE A novel bat alphaherpesvirus, Pteropus lylei-associated alphaherpesvirus (PLAHV), was isolated from urine of the fruit bat Pteropus lylei in Vietnam. The whole-genome sequence was determined and was predicted to include 72 open reading frames in the 144,008-bp genome. PLAHV is circulating in a species of fruit bats, Pteropus lylei, in Asia. This study expands the knowledge on bat-associated alphaherpesvirology.

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Characterization of a Novel Alphaherpesvirus Isolated from the Fruit Bat Pteropus lylei in Vietnam
Takuya Inagaki, Souichi Yamada, Hikaru Fujii, Tomoki Yoshikawa, Miho Shibamura, Shizuko Harada, Shuetsu Fukushi, Mai Quynh Le, Co Thach Nguyen, Thi Thu Thuy Nguyen, Thanh Thuy Nguyen, Thanh Thuy Nguyen, Van Tay Quach, Vu Dinh Thong, Kazuki Mori, Michihito Sasaki, Agus Setiyono, Ekowati Handharyani, Haruko Takeyama, Futoshi Hasebe, Masayuki Saijo
Journal of Virology Aug 2020, 94 (18) e00673-20; DOI: 10.1128/JVI.00673-20

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Characterization of a Novel Alphaherpesvirus Isolated from the Fruit Bat Pteropus lylei in Vietnam
Takuya Inagaki, Souichi Yamada, Hikaru Fujii, Tomoki Yoshikawa, Miho Shibamura, Shizuko Harada, Shuetsu Fukushi, Mai Quynh Le, Co Thach Nguyen, Thi Thu Thuy Nguyen, Thanh Thuy Nguyen, Thanh Thuy Nguyen, Van Tay Quach, Vu Dinh Thong, Kazuki Mori, Michihito Sasaki, Agus Setiyono, Ekowati Handharyani, Haruko Takeyama, Futoshi Hasebe, Masayuki Saijo
Journal of Virology Aug 2020, 94 (18) e00673-20; DOI: 10.1128/JVI.00673-20
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KEYWORDS

bat alphaherpesvirus
Pteropus lylei
Vietnam

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