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Virus-Cell Interactions

An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases

Zahra Zahid Piracha, Umar Saeed, Jumi Kim, Hyeonjoong Kwon, Yong-Joon Chwae, Hyun Woong Lee, Jin Hong Lim, Sun Park, Ho-Joon Shin, Kyongmin Kim
J.-H. James Ou, Editor
Zahra Zahid Piracha
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Umar Saeed
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Jumi Kim
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Hyeonjoong Kwon
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Yong-Joon Chwae
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Hyun Woong Lee
cDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
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Jin Hong Lim
dDepartment of General Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
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Sun Park
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Ho-Joon Shin
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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Kyongmin Kim
aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
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J.-H. James Ou
University of Southern California
Roles: Editor
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DOI: 10.1128/JVI.00926-20
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Article Information

DOI 
https://doi.org/10.1128/JVI.00926-20
PubMed 
32493816

Published By 
American Society for Microbiology Journals
History 
  • Received May 11, 2020
  • Accepted May 12, 2020
  • Published online July 30, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • J.-H. James Ou, Editor, University of Southern California

Article Versions

  • Accepted Manuscript version (June 03, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Zahra Zahid Pirachaa,b,
  2. Umar Saeeda,b,
  3. Jumi Kima,b,
  4. Hyeonjoong Kwona,b,
  5. Yong-Joon Chwaea,b,
  6. Hyun Woong Leec,
  7. Jin Hong Limd,
  8. Sun Parka,b,
  9. Ho-Joon Shina,b and
  10. Kyongmin Kima,b
  1. aDepartment of Microbiology, Ajou University School of Medicine, Suwon, South Korea
  2. bDepartment of Biomedical Science, Graduate School of Ajou University, Suwon, South Korea
  3. cDepartment of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
  4. dDepartment of General Surgery, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea
  • Address correspondence to Kyongmin Kim, kimkm{at}ajou.ac.kr.
  • Citation Piracha ZZ, Saeed U, Kim J, Kwon H, Chwae Y-J, Lee HW, Lim JH, Park S, Shin H-J, Kim K. 2020. An alternatively spliced Sirtuin 2 isoform 5 inhibits hepatitis B virus replication from cccDNA by repressing epigenetic modifications made by histone lysine methyltransferases. J Virol 94:e00926-20. https://doi.org/10.1128/JVI.00926-20.

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Article usage: June 2020 to February 2021

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Jan 2021881724
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An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases
Zahra Zahid Piracha, Umar Saeed, Jumi Kim, Hyeonjoong Kwon, Yong-Joon Chwae, Hyun Woong Lee, Jin Hong Lim, Sun Park, Ho-Joon Shin, Kyongmin Kim
Journal of Virology Jul 2020, 94 (16) e00926-20; DOI: 10.1128/JVI.00926-20

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An Alternatively Spliced Sirtuin 2 Isoform 5 Inhibits Hepatitis B Virus Replication from cccDNA by Repressing Epigenetic Modifications Made by Histone Lysine Methyltransferases
Zahra Zahid Piracha, Umar Saeed, Jumi Kim, Hyeonjoong Kwon, Yong-Joon Chwae, Hyun Woong Lee, Jin Hong Lim, Sun Park, Ho-Joon Shin, Kyongmin Kim
Journal of Virology Jul 2020, 94 (16) e00926-20; DOI: 10.1128/JVI.00926-20
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KEYWORDS

epigenetic modifications
histone lysine methyltransferases
Sirt2 isoform 5
cccDNA
hepatitis B virus

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