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Pathogenesis and Immunity

CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation

Debanjana Chakravarty, Fareeha Saadi, Soumya Kundu, Abhishek Bose, Reas Khan, Kimberly Dine, Lawrence C. Kenyon, Kenneth S. Shindler, Jayasri Das Sarma
Stacey Schultz-Cherry, Editor
Debanjana Chakravarty
aDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
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Fareeha Saadi
aDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
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Soumya Kundu
aDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
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Abhishek Bose
aDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
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Reas Khan
bDepartment of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania, USA
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Kimberly Dine
bDepartment of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania, USA
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Lawrence C. Kenyon
cDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
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Kenneth S. Shindler
bDepartment of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania, USA
dDepartment of Neurology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania, USA
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Jayasri Das Sarma
aDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
eDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
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Stacey Schultz-Cherry
St. Jude Children's Research Hospital
Roles: Editor
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DOI: 10.1128/JVI.00548-20
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Article Information

DOI 
https://doi.org/10.1128/JVI.00548-20
PubMed 
32404525

Published By 
American Society for Microbiology Journals
History 
  • Received March 27, 2020
  • Accepted May 7, 2020
  • Published online July 1, 2020.

Copyright & Usage 
Copyright © 2020 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • Stacey Schultz-Cherry, Editor, St. Jude Children's Research Hospital

Article Versions

  • Accepted Manuscript version (May 13, 2020).
  • You are viewing the most recent version of this article.

Author Information

  1. Debanjana Chakravartya,
  2. Fareeha Saadia,
  3. Soumya Kundua,
  4. Abhishek Bosea,
  5. Reas Khanb,
  6. Kimberly Dineb,
  7. Lawrence C. Kenyonc,
  8. Kenneth S. Shindlerb,d and
  9. Jayasri Das Sarmaa,e
  1. aDepartment of Biological Sciences, Indian Institute of Science Education and Research Kolkata, Mohanpur, India
  2. bDepartment of Ophthalmology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania, USA
  3. cDepartment of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
  4. dDepartment of Neurology, University of Pennsylvania Scheie Eye Institute, Philadelphia, Pennsylvania, USA
  5. eDepartment of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
  • Address correspondence to Kenneth S. Shindler, Kenneth.Shindler{at}uphs.upenn.edu, or Jayasri Das Sarma, dassarmaj{at}iiserkol.ac.in.
  • Debanjana Chakravarty and Fareeha Saadi contributed equally to this work. Author order was determined based on the relatedness of the work with Debanjana Chakravarty’s Ph.D. thesis.

  • Citation Chakravarty D, Saadi F, Kundu S, Bose A, Khan R, Dine K, Kenyon LC, Shindler KS, Das Sarma J. 2020. CD4 deficiency causes poliomyelitis and axonal blebbing in murine coronavirus-induced neuroinflammation. J Virol 94:e00548-20. https://doi.org/10.1128/JVI.00548-20.

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CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation
Debanjana Chakravarty, Fareeha Saadi, Soumya Kundu, Abhishek Bose, Reas Khan, Kimberly Dine, Lawrence C. Kenyon, Kenneth S. Shindler, Jayasri Das Sarma
Journal of Virology Jul 2020, 94 (14) e00548-20; DOI: 10.1128/JVI.00548-20

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CD4 Deficiency Causes Poliomyelitis and Axonal Blebbing in Murine Coronavirus-Induced Neuroinflammation
Debanjana Chakravarty, Fareeha Saadi, Soumya Kundu, Abhishek Bose, Reas Khan, Kimberly Dine, Lawrence C. Kenyon, Kenneth S. Shindler, Jayasri Das Sarma
Journal of Virology Jul 2020, 94 (14) e00548-20; DOI: 10.1128/JVI.00548-20
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KEYWORDS

CD4+ T cells
microglia
MHV infection
neuroinflammation
innate immune response
demyelination
host immunity
axonal blebbing
MHV
poliomyelitis
RSA59
m-CoV

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