Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Minireviews
    • JVI Classic Spotlights
    • Archive
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About JVI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Journal of Virology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Minireviews
    • JVI Classic Spotlights
    • Archive
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About JVI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Vaccines and Antiviral Agents | Spotlight

Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes

Ruchi Srivastava, Soumyabrata Roy, Pierre-Gregoire Coulon, Hawa Vahed, Swayam Prakash, Nisha Dhanushkodi, Grace J. Kim, Mona A. Fouladi, Joe Campo, Andy A. Teng, Xiaowu Liang, Hubert Schaefer, Lbachir BenMohamed
Jae U. Jung, Editor
Ruchi Srivastava
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soumyabrata Roy
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pierre-Gregoire Coulon
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hawa Vahed
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Swayam Prakash
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nisha Dhanushkodi
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Grace J. Kim
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mona A. Fouladi
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joe Campo
cAntigen Discovery Inc., Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Andy A. Teng
cAntigen Discovery Inc., Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xiaowu Liang
cAntigen Discovery Inc., Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hubert Schaefer
dIntracellular Pathogens, Robert Koch-Institute, Berlin, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lbachir BenMohamed
aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
bDepartment of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, California, USA
eInstitute for Immunology, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jae U. Jung
University of Southern California
Roles: Editor
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
DOI: 10.1128/JVI.02309-18
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Article Information

DOI 
https://doi.org/10.1128/JVI.02309-18
PubMed 
30787156

Published By 
American Society for Microbiology Journals
History 
  • Received December 27, 2018
  • Accepted February 12, 2019
  • Published online April 17, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • Jae U. Jung, Editor, University of Southern California

Article Versions

  • Accepted Manuscript version (February 20, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. Ruchi Srivastavaa,
  2. Soumyabrata Roya,
  3. Pierre-Gregoire Coulona,
  4. Hawa Vaheda,
  5. Swayam Prakasha,
  6. Nisha Dhanushkodia,
  7. Grace J. Kima,
  8. Mona A. Fouladia,
  9. Joe Campoc,
  10. Andy A. Tengc,
  11. Xiaowu Liangc,
  12. Hubert Schaeferd and
  13. Lbachir BenMohameda,b,e
  1. aLaboratory of Cellular and Molecular Immunology, Gavin Herbert Eye Institute, University of California, Irvine, School of Medicine, Irvine, California, USA
  2. bDepartment of Molecular Biology & Biochemistry, University of California, Irvine, Irvine, California, USA
  3. cAntigen Discovery Inc., Irvine, California, USA
  4. dIntracellular Pathogens, Robert Koch-Institute, Berlin, Germany
  5. eInstitute for Immunology, University of California, Irvine, School of Medicine, Irvine, California, USA
  • Address correspondence to Lbachir BenMohamed, Lbenmoha{at}uci.edu.
  • R.S., S.R., P.-G.A.C., and H.V. contributed equally to this article.

  • Citation Srivastava R, Roy S, Coulon P-G, Vahed H, Prakash S, Dhanushkodi N, Kim GJ, Fouladi MA, Campo J, Teng AA, Liang X, Schaefer H, BenMohamed L. 2019. Therapeutic mucosal vaccination of herpes simplex virus 2-infected guinea pigs with ribonucleotide reductase 2 (RR2) protein boosts antiviral neutralizing antibodies and local tissue-resident CD4+ and CD8+ TRM cells associated with protection against recurrent genital herpes. J Virol 93:e02309-18. https://doi.org/10.1128/JVI.02309-18.

View Abstract

Article usage

Article usage: February 2019 to January 2021

Rendering graph...
AbstractFullPdf
Feb 2019260039
Mar 2019417038
Apr 201950772139
May 201921844112
Jun 201919326106
Jul 20191161750
Aug 20191182958
Sep 20191071443
Oct 2019353359
Nov 201953668
Dec 201975544
Jan 202024954
Feb 202003867
Mar 202014735
Apr 202056613
May 202059834
Jun 202037210
Jul 2020410519
Aug 202049429
Sep 202039030
Oct 202069330
Nov 202097140
Dec 2020910328
Jan 202134813
PreviousNext
Back to top
Download PDF
Citation Tools
Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes
Ruchi Srivastava, Soumyabrata Roy, Pierre-Gregoire Coulon, Hawa Vahed, Swayam Prakash, Nisha Dhanushkodi, Grace J. Kim, Mona A. Fouladi, Joe Campo, Andy A. Teng, Xiaowu Liang, Hubert Schaefer, Lbachir BenMohamed
Journal of Virology Apr 2019, 93 (9) e02309-18; DOI: 10.1128/JVI.02309-18

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Journal of Virology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Rec…
(Your Name) has forwarded a page to you from Journal of Virology
(Your Name) thought you would be interested in this article in Journal of Virology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Therapeutic Mucosal Vaccination of Herpes Simplex Virus 2-Infected Guinea Pigs with Ribonucleotide Reductase 2 (RR2) Protein Boosts Antiviral Neutralizing Antibodies and Local Tissue-Resident CD4+ and CD8+ TRM Cells Associated with Protection against Recurrent Genital Herpes
Ruchi Srivastava, Soumyabrata Roy, Pierre-Gregoire Coulon, Hawa Vahed, Swayam Prakash, Nisha Dhanushkodi, Grace J. Kim, Mona A. Fouladi, Joe Campo, Andy A. Teng, Xiaowu Liang, Hubert Schaefer, Lbachir BenMohamed
Journal of Virology Apr 2019, 93 (9) e02309-18; DOI: 10.1128/JVI.02309-18
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • ABSTRACT
    • INTRODUCTION
    • RESULTS
    • DISCUSSION
    • MATERIALS AND METHODS
    • ACKNOWLEDGMENTS
    • FOOTNOTES
    • REFERENCES
  • Figures & Data
  • Info & Metrics
  • PDF

KEYWORDS

genital herpes
HSV-1
HSV-2
T cells
therapeutic vaccine
vaginal mucosa

Related Articles

Cited By...

About

  • About JVI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #Jvirology

@ASMicrobiology

       

 

JVI in collaboration with

American Society for Virology

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0022-538X; Online ISSN: 1098-5514