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Genetic Diversity and Evolution

The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses

M. Linster, E. J. A. Schrauwen, S. van der Vliet, D. F. Burke, P. Lexmond, T. M. Bestebroer, D. J. Smith, S. Herfst, B. F. Koel, R. A. M. Fouchier
Adolfo García-Sastre, Editor
M. Linster
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
bProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore
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E. J. A. Schrauwen
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
cAvans University of Applied Science, Breda, The Netherlands
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S. van der Vliet
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
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D. F. Burke
dCenter for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom
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P. Lexmond
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
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T. M. Bestebroer
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
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D. J. Smith
dCenter for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom
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S. Herfst
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
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B. F. Koel
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
eDepartment of Medical Microbiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
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R. A. M. Fouchier
aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
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Adolfo García-Sastre
Icahn School of Medicine at Mount Sinai
Roles: Editor
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DOI: 10.1128/JVI.01907-18
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Article Information

DOI 
https://doi.org/10.1128/JVI.01907-18
PubMed 
30700609

Published By 
American Society for Microbiology Journals
History 
  • Received October 30, 2018
  • Accepted January 21, 2019
  • Published online April 3, 2019.

Copyright & Usage 
Copyright © 2019 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • Adolfo García-Sastre, Editor, Icahn School of Medicine at Mount Sinai

Article Versions

  • Accepted Manuscript version (January 30, 2019).
  • You are viewing the most recent version of this article.

Author Information

  1. M. Linstera,b,
  2. E. J. A. Schrauwena,c,
  3. S. van der Vlieta,
  4. D. F. Burked,
  5. P. Lexmonda,
  6. T. M. Bestebroera,
  7. D. J. Smithd,
  8. S. Herfsta,
  9. B. F. Koela,e and
  10. R. A. M. Fouchiera
  1. aDepartment of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands
  2. bProgramme in Emerging Infectious Diseases, Duke-NUS Medical School, Singapore
  3. cAvans University of Applied Science, Breda, The Netherlands
  4. dCenter for Pathogen Evolution, Department of Zoology, University of Cambridge, Cambridge, United Kingdom
  5. eDepartment of Medical Microbiology, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, The Netherlands
  • Address correspondence to R. A. M. Fouchier, r.fouchier{at}erasmusmc.nl.
  • M.L. and E.J.A.S. contributed equally to this work.

  • Citation Linster M, Schrauwen EJA, van der Vliet S, Burke DF, Lexmond P, Bestebroer TM, Smith DJ, Herfst S, Koel BF, Fouchier RAM. 2019. The molecular basis for antigenic drift of human A/H2N2 influenza viruses. J Virol 93:e01907-18. https://doi.org/10.1128/JVI.01907-18.

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The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses
M. Linster, E. J. A. Schrauwen, S. van der Vliet, D. F. Burke, P. Lexmond, T. M. Bestebroer, D. J. Smith, S. Herfst, B. F. Koel, R. A. M. Fouchier
Journal of Virology Apr 2019, 93 (8) e01907-18; DOI: 10.1128/JVI.01907-18

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The Molecular Basis for Antigenic Drift of Human A/H2N2 Influenza Viruses
M. Linster, E. J. A. Schrauwen, S. van der Vliet, D. F. Burke, P. Lexmond, T. M. Bestebroer, D. J. Smith, S. Herfst, B. F. Koel, R. A. M. Fouchier
Journal of Virology Apr 2019, 93 (8) e01907-18; DOI: 10.1128/JVI.01907-18
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KEYWORDS

antigenic evolution
influenza virus A/H2N2
molecular drift
pandemic

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