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How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection

Cosmo Z. Buffalo, Yuichiro Iwamoto, James H. Hurley, Xuefeng Ren
Ted C. Pierson, Editor
Cosmo Z. Buffalo
Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA
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Yuichiro Iwamoto
Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA
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James H. Hurley
Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USAMolecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA
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Xuefeng Ren
Department of Molecular and Cell Biology and California Institute of Quantitative Biosciences, University of California, Berkeley, Berkeley, California, USA
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  • ORCID record for Xuefeng Ren
Ted C. Pierson
National Institute of Allergy and Infectious Diseases
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DOI: 10.1128/JVI.01322-19
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ABSTRACT

The accessory protein Nef of human immunodeficiency virus (HIV) is a primary determinant of viral pathogenesis. Nef is abundantly expressed during infection and reroutes a variety of cell surface proteins to disrupt host immunity and promote the viral replication cycle. Nef counteracts host defenses by sequestering and/or degrading its targets via the endocytic and secretory pathways. Nef does this by physically engaging a number of host trafficking proteins. Substantial progress has been achieved in identifying the targets of Nef, and a structural and mechanistic understanding of Nef’s ability to command the protein trafficking machinery has recently started to coalesce. Comparative analysis of HIV and simian immunodeficiency virus (SIV) Nef proteins in the context of recent structural advances sheds further light on both viral evolution and the mechanisms whereby trafficking is hijacked. This review describes how advances in cell and structural biology are uncovering in growing detail how Nef subverts the host immune system, facilitates virus release, and enhances viral infectivity.

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How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection
Cosmo Z. Buffalo, Yuichiro Iwamoto, James H. Hurley, Xuefeng Ren
Journal of Virology Nov 2019, 93 (24) e01322-19; DOI: 10.1128/JVI.01322-19

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How HIV Nef Proteins Hijack Membrane Traffic To Promote Infection
Cosmo Z. Buffalo, Yuichiro Iwamoto, James H. Hurley, Xuefeng Ren
Journal of Virology Nov 2019, 93 (24) e01322-19; DOI: 10.1128/JVI.01322-19
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  • Article
    • ABSTRACT
    • INTRODUCTION
    • TARGETS OF Nef COOPTATION
    • TARGETS OF Nef SUPPRESSION
    • FUTURE PERSPECTIVES
    • ACKNOWLEDGMENTS
    • REFERENCES
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KEYWORDS

antiviral restriction factors
host-pathogen
immune receptors
lentiviruses
Nef
human immunodeficiency virus
protein structure
simian immunodeficiency virus
trafficking

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Print ISSN: 0022-538X; Online ISSN: 1098-5514