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Table of Contents

October 2018; Volume 92,Issue 19

Spotlight

  • Free
    Articles of Significant Interest in This Issue
    Spotlight
    Articles of Significant Interest in This Issue

Gem

  • Free
    Emerging Proviral Roles of Caspases during Lytic Replication of Gammaherpesviruses
    Gem
    Emerging Proviral Roles of Caspases during Lytic Replication of Gammaherpesviruses
    Tate Tabtieng, Marta M. Gaglia

Structure and Assembly

  • The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein
    Structure and Assembly | Spotlight
    The RNA-Binding Protein of a Double-Stranded RNA Virus Acts like a Scaffold Protein
    Carlos P. Mata, Johann Mertens, Juan Fontana, Daniel Luque, Carolina Allende-Ballestero, David Reguera, Benes L. Trus, Alasdair C. Steven, José L. Carrascosa, José R. Castón

Genome Replication and Regulation of Viral Gene Expression

  • Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication
    Genome Replication and Regulation of Viral Gene Expression
    Mutant Cellular AP-1 Proteins Promote Expression of a Subset of Epstein-Barr Virus Late Genes in the Absence of Lytic Viral DNA Replication
    Danielle E. Lyons, Kuan-Ping Yu, Jason A. Vander Heiden, Lee Heston, Dirk P. Dittmer, Ayman El-Guindy, George Miller

Genetic Diversity and Evolution

  • Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses
    Genetic Diversity and Evolution
    Cell-Derived Viral Genes Evolve under Stronger Purifying Selection in Rhadinoviruses
    Amr Aswad, Aris Katzourakis
  • Genetic Evidence Supports Sporadic and Independent Introductions of Subtype H5 Low-Pathogenic Avian Influenza A Viruses from Wild Birds to Domestic Poultry in North America
    Genetic Diversity and Evolution
    Genetic Evidence Supports Sporadic and Independent Introductions of Subtype H5 Low-Pathogenic Avian Influenza A Viruses from Wild Birds to Domestic Poultry in North America
    Lei Li, Andrew S. Bowman, Thomas J. DeLiberto, Mary L. Killian, Scott Krauss, Jacqueline M. Nolting, Mia Kim Torchetti, Andrew M. Ramey, Andrew B. Reeves, David E. Stallknecht, Richard J. Webby, Xiu-Feng Wan

Virus-Cell Interactions

  • Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
    Virus-Cell Interactions
    Nup153 Unlocks the Nuclear Pore Complex for HIV-1 Nuclear Translocation in Nondividing Cells
    Cindy Buffone, Alicia Martinez-Lopez, Thomas Fricke, Silvana Opp, Marco Severgnini, Ingrid Cifola, Luca Petiti, Stella Frabetti, Katarzyna Skorupka, Kaneil K. Zadrozny, Barbie K. Ganser-Pornillos, Owen Pornillos, Francesca Di Nunzio, Felipe Diaz-Griffero
  • Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells
    Virus-Cell Interactions
    Middle East Respiratory Syndrome Coronavirus Spike Protein Is Not Activated Directly by Cellular Furin during Viral Entry into Target Cells
    Shutoku Matsuyama, Kazuya Shirato, Miyuki Kawase, Yutaka Terada, Kengo Kawachi, Shuetsu Fukushi, Wataru Kamitani
  • Open Access
    Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures
    Virus-Cell Interactions | Spotlight
    Herpes Simplex Virus 1 Infection Promotes the Growth of a Subpopulation of Tumor Cells in Three-Dimensional Uveal Melanoma Cultures
    Tibor Valyi-Nagy, Brian Fredericks, Aditya Ravindra, James Hopkins, Deepak Shukla, Klara Valyi-Nagy
  • Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype
    Virus-Cell Interactions
    Hepatitis B Virus Deregulates the Cell Cycle To Promote Viral Replication and a Premalignant Phenotype
    Yuchen Xia, Xiaoming Cheng, Yao Li, Kristin Valdez, Weiping Chen, T. Jake Liang
  • Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway
    Virus-Cell Interactions
    Growth-Adaptive Mutations in the Ebola Virus Makona Glycoprotein Alter Different Steps in the Virus Entry Pathway
    John B. Ruedas, Catherine E. Arnold, Gustavo Palacios, John H. Connor
  • Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly
    Virus-Cell Interactions
    Sendai Virus V Protein Inhibits the Secretion of Interleukin-1β by Preventing NLRP3 Inflammasome Assembly
    Takayuki Komatsu, Yukie Tanaka, Yoshinori Kitagawa, Naoki Koide, Yoshikazu Naiki, Naoko Morita, Bin Gotoh, Takashi Yokochi
  • Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells
    Virus-Cell Interactions
    Engineered Oncolytic Poliovirus PVSRIPO Subverts MDA5-Dependent Innate Immune Responses in Cancer Cells
    Ross W. Walton, Michael C. Brown, Matthew T. Sacco, Matthias Gromeier
  • Open Access
    The S2 Subunit of Infectious Bronchitis Virus Beaudette Is a Determinant of Cellular Tropism
    Virus-Cell Interactions
    The S2 Subunit of Infectious Bronchitis Virus Beaudette Is a Determinant of Cellular Tropism
    Erica Bickerton, Helena J. Maier, Phoebe Stevenson-Leggett, Maria Armesto, Paul Britton
  • Open Access
    Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus
    Virus-Cell Interactions
    Inosine Triphosphate Pyrophosphatase Dephosphorylates Ribavirin Triphosphate and Reduced Enzymatic Activity Potentiates Mutagenesis in Hepatitis C Virus
    Kristina Nyström, Paulina H. Wanrooij, Jesper Waldenström, Ludmila Adamek, Sofia Brunet, Joanna Said, Staffan Nilsson, Megan Wind-Rotolo, Kristoffer Hellstrand, Helene Norder, Ka-Wei Tang, Martin Lagging
  • Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity
    Virus-Cell Interactions
    Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity
    Hui Yuan, Jia You, Hongjuan You, Chunfu Zheng
  • Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans
    Virus-Cell Interactions
    Functional Evolution of the 2009 Pandemic H1N1 Influenza Virus NS1 and PA in Humans
    Aitor Nogales, Luis Martinez-Sobrido, Kevin Chiem, David J. Topham, Marta L. DeDiego
  • Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity
    Virus-Cell Interactions
    Strategy of Human Cytomegalovirus To Escape Interferon Beta-Induced APOBEC3G Editing Activity
    Sara Pautasso, Ganna Galitska, Valentina Dell'Oste, Matteo Biolatti, Rachele Cagliani, Diego Forni, Marco De Andrea, Marisa Gariglio, Manuela Sironi, Santo Landolfo

Cellular Response to Infection

  • MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2
    Cellular Response to Infection
    MicroRNA hsa-miR-324-5p Suppresses H5N1 Virus Replication by Targeting the Viral PB1 and Host CUEDC2
    Ashish Kumar, Akhilesh Kumar, Harshad Ingle, Sushil Kumar, Richa Mishra, Mahendra Kumar Verma, Debasis Biswas, Nachimuthu Senthil Kumar, Anamika Mishra, Ashwin Ashok Raut, Akinori Takaoka, Himanshu Kumar
  • Expression of the Vaccinia Virus Antiapoptotic F1 Protein Is Blocked by Protein Kinase R in the Absence of the Viral E3 Protein
    Cellular Response to Infection
    Expression of the Vaccinia Virus Antiapoptotic F1 Protein Is Blocked by Protein Kinase R in the Absence of the Viral E3 Protein
    Ninad Mehta, Emeka K. Enwere, Theodore Dos Santos, Holly A. Saffran, Bart Hazes, David Evans, Michele Barry, James R. Smiley

Transformation and Oncogenesis

  • Open Access
    Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells
    Transformation and Oncogenesis | Spotlight
    Enhancer Control of MicroRNA miR-155 Expression in Epstein-Barr Virus-Infected B Cells
    C. David Wood, Thomas Carvell, Andrea Gunnell, Opeoluwa O. Ojeniyi, Cameron Osborne, Michelle J. West

Prions

  • Open Access
    Oral Prion Neuroinvasion Occurs Independently of PrP<sup>C</sup> Expression in the Gut Epithelium
    Prions
    Oral Prion Neuroinvasion Occurs Independently of PrPC Expression in the Gut Epithelium
    Alison Marshall, Barry M. Bradford, Alan R. Clarke, Jean C. Manson, Neil A. Mabbott

Vaccines and Antiviral Agents

  • Analysis of Complement-Mediated Lysis of Simian Immunodeficiency Virus (SIV) and SIV-Infected Cells Reveals Sex Differences in Vaccine-Induced Immune Responses in Rhesus Macaques
    Vaccines and Antiviral Agents
    Analysis of Complement-Mediated Lysis of Simian Immunodeficiency Virus (SIV) and SIV-Infected Cells Reveals Sex Differences in Vaccine-Induced Immune Responses in Rhesus Macaques
    Leia K. Miller-Novak, Jishnu Das, Thomas A. Musich, Thorsten Demberg, Joshua A. Weiner, David J. Venzon, Venkatramanan Mohanram, Diego A. Vargas-Inchaustegui, Iskra Tuero, Margaret E. Ackerman, Galit Alter, Marjorie Robert-Guroff
  • Multiantigenic Modified Vaccinia Virus Ankara Vaccine Vectors To Elicit Potent Humoral and Cellular Immune Reponses against Human Cytomegalovirus in Mice
    Vaccines and Antiviral Agents
    Multiantigenic Modified Vaccinia Virus Ankara Vaccine Vectors To Elicit Potent Humoral and Cellular Immune Reponses against Human Cytomegalovirus in Mice
    Flavia Chiuppesi, Jenny Nguyen, Soojin Park, Heidi Contreras, Mindy Kha, Zhuo Meng, Teodora Kaltcheva, Angelina Iniguez, Joy Martinez, Corinna La Rosa, Felix Wussow, Don J. Diamond
  • SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
    Vaccines and Antiviral Agents | Spotlight
    SOSIP Changes Affect Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Conformation and CD4 Engagement
    Nirmin Alsahafi, Sai Priya Anand, Luis Castillo-Menendez, Myriam Maude Verly, Halima Medjahed, Jérémie Prévost, Alon Herschhorn, Jonathan Richard, Arne Schön, Bruno Melillo, Ernesto Freire, Amos B. Smith, Joseph Sodroski, Andrés Finzi

Pathogenesis and Immunity

  • Characterization of the Plasmacytoid Dendritic Cell Response to Transmitted/Founder and Nontransmitted Variants of HIV-1
    Pathogenesis and Immunity
    Characterization of the Plasmacytoid Dendritic Cell Response to Transmitted/Founder and Nontransmitted Variants of HIV-1
    Jordan Ari Schwartz, Hongliang Zhang, Zachary Ende, Martin J. Deymier, Terry Lee, Joel Singer, Tony Mazzulli, Eric Hunter, Mario A. Ostrowski
  • Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity
    Pathogenesis and Immunity
    Two Conserved Amino Acids within the NSs of Severe Fever with Thrombocytopenia Syndrome Phlebovirus Are Essential for Anti-interferon Activity
    Miyu Moriyama, Manabu Igarashi, Takumi Koshiba, Takashi Irie, Ayato Takada, Takeshi Ichinohe
  • Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection
    Pathogenesis and Immunity
    Antisense-Derived HIV-1 Cryptic Epitopes Are Not Major Drivers of Viral Evolution during the Acute Phase of Infection
    Binghao J. Peng, Jonathan M. Carlson, Michael K. P. Liu, Feng Gao, Nilu Goonetilleke, Andrew J. McMichael, Persephone Borrow, Jill Gilmour, Sonya L. Heath, Eric Hunter, Anju Bansal, Paul A. Goepfert
  • Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection
    Pathogenesis and Immunity
    Pol-Driven Replicative Capacity Impacts Disease Progression in HIV-1 Subtype C Infection

    Identification of viral mutations that compromise HIV's ability to replicate may aid rational vaccine design. However, while certain escape mutations in Gag have been shown to reduce HIV replication and influence clinical progression, less is known about the consequences of mutations that naturally arise in other HIV proteins. Pol is a highly conserved protein, but the impact of Pol function on HIV disease progression is not well...

    Doty B. A. Ojwach, Daniel MacMillan, Tarylee Reddy, Vladimir Novitsky, Zabrina L. Brumme, Mark A. Brockman, Thumbi Ndung'u, Jaclyn K. Mann
  • Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape Mutations <em>In Ovo</em>
    Pathogenesis and Immunity
    Sera from Individuals with Narrowly Focused Influenza Virus Antibodies Rapidly Select Viral Escape Mutations In Ovo
    Amy K. F. Davis, Kevin McCormick, Megan E. Gumina, Joshua G. Petrie, Emily T. Martin, Katherine S. Xue, Jesse D. Bloom, Arnold S. Monto, Frederic D. Bushman, Scott E. Hensley
  • Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity
    Pathogenesis and Immunity
    Phosphatase Cdc25A Negatively Regulates the Antiviral Immune Response by Inhibiting TBK1 Activity
    Dandan Qi, Lei Hu, Tong Jiao, Tinghong Zhang, Xiaomei Tong, Xin Ye
  • Open Access
    Testicular Degeneration and Infertility following Arbovirus Infection
    Pathogenesis and Immunity | Spotlight
    Testicular Degeneration and Infertility following Arbovirus Infection
    Giantonella Puggioni, Davide Pintus, Eleonora Melzi, Giorgio Meloni, Angela Maria Rocchigiani, Caterina Maestrale, Daniela Manunta, Giovanni Savini, Maria Dattena, Annalisa Oggiano, Massimo Palmarini, Ciriaco Ligios
  • Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections
    Pathogenesis and Immunity
    Kaposi's Sarcoma-Associated Herpesvirus Latency Locus Renders B Cells Hyperresponsive to Secondary Infections
    Sang-Hoon Sin, Anthony B. Eason, Rachele Bigi, Yongbaek Kim, SunAh Kang, Kelly Tan, Tischan A. Seltzer, Raman Venkataramanan, Hyowon An, Dirk P. Dittmer

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    Masthead
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Journal of Virology: 92 (19)

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volume 92, issue 19
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