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Vaccines and Antiviral Agents

Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice

Julia C. Frei, Ariel S. Wirchnianski, Jennifer Govero, Olivia Vergnolle, Kimberly A. Dowd, Theodore C. Pierson, Margaret Kielian, Mark E. Girvin, Michael S. Diamond, Jonathan R. Lai
Terence S. Dermody, Editor
Julia C. Frei
aDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
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Ariel S. Wirchnianski
aDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
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Jennifer Govero
bDepartment of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
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Olivia Vergnolle
aDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
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Kimberly A. Dowd
fViral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Theodore C. Pierson
fViral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Margaret Kielian
cDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
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  • ORCID record for Margaret Kielian
Mark E. Girvin
aDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
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Michael S. Diamond
bDepartment of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
dDepartment of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
eDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
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Jonathan R. Lai
aDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
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Terence S. Dermody
University of Pittsburgh School of Medicine
Roles: Editor
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DOI: 10.1128/JVI.01023-18
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Article Information

DOI 
https://doi.org/10.1128/JVI.01023-18
PubMed 
29976679

Published By 
American Society for Microbiology Journals
History 
  • Received June 12, 2018
  • Accepted June 29, 2018
  • Published online August 29, 2018.

Copyright & Usage 
Copyright © 2018 American Society for Microbiology. All Rights Reserved.
Editors and / or Reviewers 
  • Terence S. Dermody, Editor, University of Pittsburgh School of Medicine

Article Versions

  • Accepted Manuscript version (July 05, 2018).
  • You are viewing the most recent version of this article.

Author Information

  1. Julia C. Freia,
  2. Ariel S. Wirchnianskia,
  3. Jennifer Goverob,
  4. Olivia Vergnollea,
  5. Kimberly A. Dowdf,
  6. Theodore C. Piersonf,
  7. Margaret Kielianc,
  8. Mark E. Girvina,
  9. Michael S. Diamondb,d,e and
  10. Jonathan R. Laia
  1. aDepartment of Biochemistry, Albert Einstein College of Medicine, Bronx, New York, USA
  2. bDepartment of Medicine, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
  3. cDepartment of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA
  4. dDepartment of Molecular Microbiology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
  5. eDepartment of Pathology and Immunology, Washington University in St. Louis School of Medicine, St. Louis, Missouri, USA
  6. fViral Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
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Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice
Julia C. Frei, Ariel S. Wirchnianski, Jennifer Govero, Olivia Vergnolle, Kimberly A. Dowd, Theodore C. Pierson, Margaret Kielian, Mark E. Girvin, Michael S. Diamond, Jonathan R. Lai
Journal of Virology Aug 2018, 92 (18) e01023-18; DOI: 10.1128/JVI.01023-18

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Engineered Dengue Virus Domain III Proteins Elicit Cross-Neutralizing Antibody Responses in Mice
Julia C. Frei, Ariel S. Wirchnianski, Jennifer Govero, Olivia Vergnolle, Kimberly A. Dowd, Theodore C. Pierson, Margaret Kielian, Mark E. Girvin, Michael S. Diamond, Jonathan R. Lai
Journal of Virology Aug 2018, 92 (18) e01023-18; DOI: 10.1128/JVI.01023-18
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KEYWORDS

dengue virus
domain IIII
immunogen
phage display
protein engineering
vaccine

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