Journal of Virology: 92 (1)

January 2018; Volume 92,Issue 1

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Articles of Significant Interest Selected from This Issue by the Editors

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Open Access

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Impacts of Genome-Wide Analyses on Our Understanding of Human Herpesvirus Diversity and Evolution
Daniel W. Renner, Moriah L. Szpara

Structure and Assembly

Structure and Assembly
Mutations in the Influenza A Virus M1 Protein Enhance Virus Budding To Complement Lethal Mutations in the M2 Cytoplasmic Tail
Hsuan Liu, Michael L. Grantham, Andrew Pekosz
Open Access

Structure and Assembly | Spotlight
Deep Sequencing of Foot-and-Mouth Disease Virus Reveals RNA Sequences Involved in Genome Packaging
Grace Logan, Joseph Newman, Caroline F. Wright, Lidia Lasecka-Dykes, Daniel T. Haydon, Eleanor M. Cottam, Tobias J. Tuthill
Structure and Assembly
Functional Carboxy-Terminal Fluorescent Protein Fusion to Pseudorabies Virus Small Capsid Protein VP26
Ian B. Hogue, Jolie Jean, Andrew D. Esteves, Nikhila S. Tanneti, Julian Scherer, Lynn W. Enquist
Open Access

Structure and Assembly
NS3 from Hepatitis C Virus Strain JFH-1 Is an Unusually Robust Helicase That Is Primed To Bind and Unwind Viral RNA
Ting Zhou, Xiaoming Ren, Rebecca L. Adams, Anna Marie Pyle
Structure and Assembly
The Postfusion Structure of the Heartland Virus Gc Glycoprotein Supports Taxonomic Separation of the Bunyaviral Families Phenuiviridae and Hantaviridae
Yaohua Zhu, Yan Wu, Yan Chai, Jianxun Qi, Ruchao Peng, Wen-Hai Feng, George Fu Gao

Genome Replication and Regulation of Viral Gene Expression

Genome Replication and Regulation of Viral Gene Expression
Human Embryonic Stem Cell-Derived Neurons Are Highly Permissive for Varicella-Zoster Virus Lytic Infection
Tomohiko Sadaoka, Cindi L. Schwartz, Labchan Rajbhandari, Arun Venkatesan, Jeffrey I. Cohen
Genome Replication and Regulation of Viral Gene Expression
Mechanisms of HERV-K (HML-2) Transcription during Human Mammary Epithelial Cell Transformation
Meagan Montesion, Neeru Bhardwaj, Zachary H. Williams, Charlotte Kuperwasser, John M. Coffin
Genome Replication and Regulation of Viral Gene Expression
Distribution of Hepatitis B Virus Nuclear DNA
Mingming Li, Ji A. Sohn, Christoph Seeger
Genome Replication and Regulation of Viral Gene Expression
Rice Stripe Tenuivirus Has a Greater Tendency To Use the Prime-and-Realign Mechanism in Transcription of Genomic than in Transcription of Antigenomic Template RNAs
Xiaojuan Liu, Jing Jin, Ping Qiu, Fangluan Gao, Wenzhong Lin, Guohui Xie, Simiao He, Shunmin Liu, Zhenguo Du, Zujian Wu

Virus-Cell Interactions

Virus-Cell Interactions
A Tyrosine-Based Trafficking Motif of the Tegument Protein pUL71 Is Crucial for Human Cytomegalovirus Secondary Envelopment
Andrea N. Dietz, Clarissa Villinger, Stefan Becker, Manfred Frick, Jens von Einem
Virus-Cell Interactions | Spotlight
Both Sphingomyelin and Cholesterol in the Host Cell Membrane Are Essential for Rubella Virus Entry
Noriyuki Otsuki, Masafumi Sakata, Kyoko Saito, Kiyoko Okamoto, Yoshio Mori, Kentaro Hanada, Makoto Takeda
Virus-Cell Interactions
Hepatitis C Virus Replication Depends on Endosomal Cholesterol Homeostasis
Ina Karen Stoeck, Ji-Young Lee, Keisuke Tabata, Inés Romero-Brey, David Paul, Philipp Schult, Volker Lohmann, Lars Kaderali, Ralf Bartenschlager
Virus-Cell Interactions | Spotlight
Structure-Function Dissection of Pseudorabies Virus Glycoprotein B Fusion Loops
Melina Vallbracht, Delphine Brun, Matteo Tassinari, Marie-Christine Vaney, Gérard Pehau-Arnaudet, Pablo Guardado-Calvo, Ahmed Haouz, Barbara G. Klupp, Thomas C. Mettenleiter, Felix A. Rey, Marija Backovic
Virus-Cell Interactions
Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion
Imane El Kasmi, Bita Khadivjam, Miki Lackman, Johanne Duron, Eric Bonneil, Pierre Thibault, Roger Lippé
Virus-Cell Interactions
HIV-1 Infection of Primary CD4⁺ T Cells Regulates the Expression of Specific Human Endogenous Retrovirus HERV-K (HML-2) Elements
George R. Young, Sandra N. Terry, Lara Manganaro, Alvaro Cuesta-Dominguez, Gintaras Deikus, Dabeiba Bernal-Rubio, Laura Campisi, Ana Fernandez-Sesma, Robert Sebra, Viviana Simon, Lubbertus C. F. Mulder
Virus-Cell Interactions
Residues 28 to 39 of the Extracellular Loop 1 of Chicken Na⁺/H⁺ Exchanger Type I Mediate Cell Binding and Entry of Subgroup J Avian Leukosis Virus
Xiaolu Guan, Yao Zhang, Mengmeng Yu, Chaoqi Ren, Yanni Gao, Bingling Yun, Yongzhen Liu, Yongqiang Wang, Xiaole Qi, Changjun Liu, Hongyu Cui, Yanping Zhang, Li Gao, Kai Li, Qing Pan, Baoshan Zhang, Xiaomei Wang, Yulong Gao
Virus-Cell Interactions
Distinct Roles of Cellular ESCRT-I and ESCRT-III Proteins in Efficient Entry and Egress of Budded Virions of Autographa californica Multiple Nucleopolyhedrovirus
Qi Yue, Qianlong Yu, Qi Yang, Ye Xu, Ya Guo, Gary W. Blissard, Zhaofei Li
Virus-Cell Interactions
Innate Sensing of Influenza A Virus Hemagglutinin Glycoproteins by the Host Endoplasmic Reticulum (ER) Stress Pathway Triggers a Potent Antiviral Response via ER-Associated Protein Degradation
Dylan A. Frabutt, Bin Wang, Sana Riaz, Richard C. Schwartz, Yong-Hui Zheng
Open Access

Virus-Cell Interactions
Stability and Expression Levels of HLA-C on the Cell Membrane Modulate HIV-1 Infectivity
Francesca Parolini, Priscilla Biswas, Michela Serena, Francesca Sironi, Valentina Muraro, Elisabetta Guizzardi, Lucia Cazzoletti, Maria Teresa Scupoli, Davide Gibellini, Elisabetta Ugolotti, Roberto Biassoni, Alberto Beretta, Mauro Malnati, Maria Grazia Romanelli, Donato Zipeto

Cellular Response to Infection

Cellular Response to Infection
Myeloid Dendritic Cells Repress Human Cytomegalovirus Gene Expression and Spread by Releasing Interferon-Unrelated Soluble Antiviral Factors
Bahram Kasmapour, Tobias Kubsch, Ulfert Rand, Britta Eiz-Vesper, Martin Messerle, Florian W. R. Vondran, Bettina Wiegmann, Axel Haverich, Luka Cicin-Sain
Cellular Response to Infection
Murine Hepatitis Virus nsp14 Exoribonuclease Activity Is Required for Resistance to Innate Immunity
James Brett Case, Yize Li, Ruth Elliott, Xiaotao Lu, Kevin W. Graepel, Nicole R. Sexton, Everett Clinton Smith, Susan R. Weiss, Mark R. Denison
Cellular Response to Infection
MicroRNA gga-miR-130b Suppresses Infectious Bursal Disease Virus Replication via Targeting of the Viral Genome and Cellular Suppressors of Cytokine Signaling 5
Mengjiao Fu, Bin Wang, Xiang Chen, Zhiyuan He, Yongqiang Wang, Xiaoqi Li, Hong Cao, Shijun J. Zheng
Open Access

Cellular Response to Infection | Spotlight
Viperin Targets Flavivirus Virulence by Inducing Assembly of Noninfectious Capsid Particles
Kirstin Vonderstein, Emma Nilsson, Philipp Hubel, Larsård Nygård Skalman, Arunkumar Upadhyay, Jenny Pasto, Andreas Pichlmair, Richard Lundmark, Anna K. Överby

Gene Delivery

Gene Delivery
Foamy Virus Vector Carries a Strong Insulator in Its Long Terminal Repeat Which Reduces Its Genotoxic Potential
Michael Aaron Goodman, Paritha Arumugam, Devin Marie Pillis, Anastacia Loberg, Mohammed Nasimuzzaman, Danielle Lynn, Johannes Christiaan Maria van der Loo, Phillip Joseph Dexheimer, Mehdi Keddache, Thomas Roy Bauer, Dennis Durand Hickstein, David William Russell, Punam Malik

Prions

Prions
Prion Protein Devoid of the Octapeptide Repeat Region Delays Bovine Spongiform Encephalopathy Pathogenesis in Mice
Hideyuki Hara, Hironori Miyata, Nandita Rani Das, Junji Chida, Tatenobu Yoshimochi, Keiji Uchiyama, Hitomi Watanabe, Gen Kondoh, Takashi Yokoyama, Suehiro Sakaguchi
Prions
Flow Cytometric Detection of PrP^Sc in Neurons and Glial Cells from Prion-Infected Mouse Brains
Takeshi Yamasaki, Akio Suzuki, Rie Hasebe, Motohiro Horiuchi

Vaccines and Antiviral Agents

Vaccines and Antiviral Agents
HIV-Exposed Infants Vaccinated with an MF59/Recombinant gp120 Vaccine Have Higher-Magnitude Anti-V1V2 IgG Responses than Adults Immunized with the Same Vaccine
Erin P. McGuire, Youyi Fong, Christopher Toote, Coleen K. Cunningham, Elizabeth J. McFarland, William Borkowsky, Susan Barnett, Hannah L. Itell, Amit Kumar, Glenda Gray, M. Julianna McElrath, Georgia D. Tomaras, Sallie R. Permar, Genevieve G. Fouda
Vaccines and Antiviral Agents
Structure, Immunogenicity, and Protective Mechanism of an Engineered Enterovirus 71-Like Particle Vaccine Mimicking 80S Empty Capsid
Xiaoli Wang, Zhiqiang Ku, Xiang Zhang, Xiaohua Ye, Jinhuan Chen, Qingwei Liu, Wei Zhang, Chao Zhang, Zhenglin Fu, Xia Jin, Yao Cong, Zhong Huang
Vaccines and Antiviral Agents
Screening for Neuraminidase Inhibitor Resistance Markers among Avian Influenza Viruses of the N4, N5, N6, and N8 Neuraminidase Subtypes
Won-Suk Choi, Ju Hwan Jeong, Jin Jung Kwon, Su Jeong Ahn, Khristine Kaith S. Lloren, Hyeok-Il Kwon, Hee Bok Chae, Jungwon Hwang, Myung Hee Kim, Chul-Joong Kim, Richard J. Webby, Elena A. Govorkova, Young Ki Choi, Yun Hee Baek, Min-Suk Song
Vaccines and Antiviral Agents
Epistastic Interactions within the Junín Virus Envelope Glycoprotein Complex Provide an Evolutionary Barrier to Reversion in the Live-Attenuated Candid#1 Vaccine
Joanne York, Jack H. Nunberg

Pathogenesis and Immunity

Pathogenesis and Immunity | Spotlight
Rotavirus Degrades Multiple Interferon (IFN) Type Receptors To Inhibit IFN Signaling and Protects against Mortality from Endotoxin in Suckling Mice
Adrish Sen, Ayushi Sharma, Harry B. Greenberg
Pathogenesis and Immunity
Resistance of Major Histocompatibility Complex Class B (MHC-B) to Nef-Mediated Downregulation Relative to that of MHC-A Is Conserved among Primate Lentiviruses and Influences Antiviral T Cell Responses in HIV-1-Infected Individuals
Francis Mwimanzi, Mako Toyoda, Macdonald Mahiti, Jaclyn K. Mann, Jeffrey N. Martin, David Bangsberg, Mark A. Brockman, Philip Goulder, Frank Kirchhoff, Zabrina L. Brumme, Thumbi Ndung'u, Takamasa Ueno
Pathogenesis and Immunity
Infectious Laryngotracheitis Virus Viral Chemokine-Binding Protein Glycoprotein G Alters Transcription of Key Inflammatory Mediators In Vitro and In Vivo
Mauricio J. C. Coppo, Joanne M. Devlin, Alistair R. Legione, Paola K. Vaz, Sang-Won Lee, José A. Quinteros, James R. Gilkerson, Nino Ficorilli, Patrick C. Reading, Amir H. Noormohammadi, Carol A. Hartley
Pathogenesis and Immunity
Structural Basis for Escape of Human Astrovirus from Antibody Neutralization: Broad Implications for Rational Vaccine Design
Walter A. Bogdanoff, Edmundo I. Perez, Tomás López, Carlos F. Arias, Rebecca M. DuBois

Author Corrections

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Author Correction
Correction for Mounce et al., “A Conserved Gammaherpesvirus Protein Kinase Targets Histone Deacetylases 1 and 2 To Facilitate Viral Replication in Primary Macrophages”
Bryan C. Mounce, Wadzanai P. Mboko, Tarin M. Bigley, Scott S. Terhune, Vera L. Tarakanova
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Author Correction
Correction for Subba-Reddy et al., “VPg-Primed RNA Synthesis of Norovirus RNA-Dependent RNA Polymerases by Using a Novel Cell-Based Assay”
Chennareddy V. Subba-Reddy, Ian Goodfellow, C. Cheng Kao
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Author Correction
Correction for Ver et al., “The Cellular Factor NXP2/MORC3 Is a Positive Regulator of Influenza Virus Multiplication”
Lorena S. Ver, Laura Marcos-Villar, Sara Landeras-Bueno, Amelia Nieto, Juan Ortín
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Author Correction
Correction for Hraber et al., “Panels of HIV-1 Subtype C Env Reference Strains for Standardized Neutralization Assessments”
Peter Hraber, Cecilia Rademeyer, Carolyn Williamson, Michael S. Seaman, Raphael Gottardo, Haili Tang, Kelli Greene, Hongmei Gao, Celia LaBranche, John R. Mascola, Lynn Morris, David C. Montefiori, Bette Korber

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Table of Contents

Spotlight

Minireview

Structure and Assembly

Genome Replication and Regulation of Viral Gene Expression

Virus-Cell Interactions

Cellular Response to Infection

Gene Delivery

Prions

Vaccines and Antiviral Agents

Pathogenesis and Immunity

Author Corrections

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