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Pathogenesis and Immunity

Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels

W. Widagdo, V. Stalin Raj, Debby Schipper, Kimberley Kolijn, Geert J. L. H. van Leenders, Berend J. Bosch, Albert Bensaid, Joaquim Segalés, Wolfgang Baumgärtner, Albert D. M. E. Osterhaus, Marion P. Koopmans, Judith M. A. van den Brand, Bart L. Haagmans
S. Perlman, Editor
W. Widagdo
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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V. Stalin Raj
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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Debby Schipper
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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Kimberley Kolijn
bDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands
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Geert J. L. H. van Leenders
bDepartment of Pathology, Erasmus MC, Rotterdam, The Netherlands
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Berend J. Bosch
cVirology Division, Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands
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Albert Bensaid
dIRTA, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain
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Joaquim Segalés
eUAB, Centre de Recerca en Sanitat Animal (CReSA), Unitat Mixta IRTA-UAB, Campus de la Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain
fDepartament de Sanitat i Anatomia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra (Cerdanyola del Vallès), Spain
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Wolfgang Baumgärtner
gDepartment of Pathology, University of Veterinary Medicine, Hannover, Germany
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Albert D. M. E. Osterhaus
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
hArtemis One Health, Utrecht, The Netherlands
iCenter for Infection Medicine and Zoonoses Research (RIZ), University of Veterinary Medicine, Hannover, Germany
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Marion P. Koopmans
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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Judith M. A. van den Brand
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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Bart L. Haagmans
aDepartment of Viroscience, Erasmus MC, Rotterdam, The Netherlands
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S. Perlman
Roles: Editor
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DOI: 10.1128/JVI.02994-15
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ABSTRACT

Middle East respiratory syndrome coronavirus (MERS-CoV) is not efficiently transmitted between humans, but it is highly prevalent in dromedary camels. Here we report that the MERS-CoV receptor—dipeptidyl peptidase 4 (DPP4)—is expressed in the upper respiratory tract epithelium of camels but not in that of humans. Lack of DPP4 expression may be the primary cause of limited MERS-CoV replication in the human upper respiratory tract and hence restrict transmission.

FOOTNOTES

    • Received 26 November 2015.
    • Accepted 8 February 2016.
    • Accepted manuscript posted online 17 February 2016.
  • Address correspondence to Bart L. Haagmans b.haagmans{at}erasmusmc.nl.
  • Citation Widagdo W, Raj VS, Schipper D, Kolijn K, van Leenders GJLH, Bosch BJ, Bensaid A, Segalés J, Baumgärtner W, Osterhaus ADME, Koopmans MP, van den Brand JMA, Haagmans BL. 2016. Differential expression of the Middle East respiratory syndrome coronavirus receptor in the upper respiratory tracts of humans and dromedary camels. J Virol 90:4838–4842. doi:10.1128/JVI.02994-15.

  • Copyright © 2016, American Society for Microbiology. All Rights Reserved.
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Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels
W. Widagdo, V. Stalin Raj, Debby Schipper, Kimberley Kolijn, Geert J. L. H. van Leenders, Berend J. Bosch, Albert Bensaid, Joaquim Segalés, Wolfgang Baumgärtner, Albert D. M. E. Osterhaus, Marion P. Koopmans, Judith M. A. van den Brand, Bart L. Haagmans
Journal of Virology Apr 2016, 90 (9) 4838-4842; DOI: 10.1128/JVI.02994-15

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Differential Expression of the Middle East Respiratory Syndrome Coronavirus Receptor in the Upper Respiratory Tracts of Humans and Dromedary Camels
W. Widagdo, V. Stalin Raj, Debby Schipper, Kimberley Kolijn, Geert J. L. H. van Leenders, Berend J. Bosch, Albert Bensaid, Joaquim Segalés, Wolfgang Baumgärtner, Albert D. M. E. Osterhaus, Marion P. Koopmans, Judith M. A. van den Brand, Bart L. Haagmans
Journal of Virology Apr 2016, 90 (9) 4838-4842; DOI: 10.1128/JVI.02994-15
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