Article Figures & Data
Figures
- FIG 1
Ebola virus mortality and GBV-C coinfection status by age.
Tables
- TABLE 1
EBOV patients coinfected with GBV-C
Patient ID SRR ID(s)a No. of raw GBV-C reads No. of unique GBV-C reads No. of EBOV reads Patient outcome G3670.1 1553450 191 159 282,289 Discharged G3765.2 1553501, 1553502 2,161 1,749 2,490 Discharged G3789.1 1553525, 1553526 343 325 5,508 Discharged G3796 1553529, 1553530 79,619 40,538 2,090,829 Discharged G3819 1553559, 1553559 601 554 33,172 Discharged G3821 1553563, 1553564 4,529 4,047 99,766 Discharged G3850 1553595, 1553596 797 673 7,363 Discharged G3764 1553499, 1553500 64 55 5,402,195 Died G3795 1553527, 1553528 2,671 774 1,005,042 Died G3808 1553543, 1553544 6,454 5,515 819,166 Died G3825 1553569, 1553570, 1553571, 1553572 5,093 4,069 2,177,336 Died G3826 1553573, 1553574 29,752 27,149 867,174 Died G3845 1553589, 1553590 2,794 2,137 3,377,501 Died ↵a SRR, sequencing run.
- TABLE 2
EBOV patients not coinfected with GBV-C
Patient ID SRR IDsa No. of raw GBV-C reads No. of unique GBV-C reads No. of EBOV reads Patient outcome G3769 1553503, 1553504, 1553505, 1553506, 1553507, 1553508, 1553509, 1553510 7 0 4,218,762 Discharged G3799 1553533, 1553534 29 5 1,160,025 Discharged G3805 1553537, 1553538, 1553539, 1553540 0 0 6,054 Discharged G3809 1553545, 1553546 6 0 11,344 Discharged G3810 1553547, 1553548, 1553549, 1553550 0 0 503,396 Discharged G3817 1553555, 1553556 1 0 920,637 Discharged G3857 1553603, 1553604 4 2 9,115 Discharged NM042 1553605, 1553606, 1553607, 1553608, 1553609, 1553610 0 0 574,137 Discharged EM112 1553429, 1553430 2 0 4,495,065 Died EM121 1553439, 1553440 0 0 3,393,644 Died EM124 1553441, 1553442, 1553443, 1553444, 1553445, 1553446, 1553447, 1553448 4 0 2,370,521 Died G3676 1553451, 1553452, 1553453, 1553454 0 0 1,753,365 Died G3677 1553455, 1553456, 1553457, 1553458 2 0 2,195,013 Died G3707 1553471, 1553472 4 0 1,848,917 Died G3713 1553473, 1553474, 1553475, 1553476, 1553477, 1553478 4 0 11,650,343 Died G3724 1553479, 1553480 0 0 5,237,956 Died G3735 1553485, 1553486, 1553487, 1553488 0 0 11,945,730 Died G3752 1553495, 1553496 2 1 1,181,649 Died G3770 1553511, 1553512, 1553513, 1553514 15 4 9,932,933 Died G3798 1553531, 1553532 2 0 1,124,997 Died G3800 1553535, 1553536 9 0 890,300 Died G3807 1553541, 1553542 0 0 822,652 Died G3814 1553551, 1553552 0 0 13,286 Died G3816 1553553, 1553554 0 0 10,101 Died G3818 1553557, 1553558 0 0 2,398,770 Died G3820 1553561, 1553562 2 0 1,890,862 Died G3822 1553565, 1553566 0 0 3,417,852 Died G3823 1553567, 1553568 0 0 4,672,245 Died G3827 1553575, 1553576 0 0 657,986 Died G3829 1553577, 1553578 0 0 1,619,423 Died G3834 1553581, 1553582 0 0 646,694 Died G3838 1553583, 1553584 4 1 2,234,396 Died G3840 1553585, 1553586 0 0 2,978,090 Died G3846 1553591, 1553592 6 0 2,829,761 Died G3848 1553593, 1553594 0 0 3,013,745 Died G3851 1553597, 1553598 0 0 393,873 Died a SRR, sequencing run.
- TABLE 3
Pairwise comparison of percentages of nucleotide identity for GBV-C consensus sequences
Patient ID % nucleotide identity to GBV-C consensus sequencea: G3670.1 G3764 G3765.2 G3789.1 G3795 G3796 G3808 G3819 G3821 G3825 G3826 G3845 G3850 G3670.1 100 G3764 90.86 100 G3765.2 92.46 91.36 100 G3789.1 86.96 87.89 88.28 100 G3795 91.30 90.92 92.79 88.11 100 G3796 91.36 90.97 92.79 88.11 98.46 100 G3808 94.22 91.52 92.68 88.61 92.18 92.13 100 G3819 91.36 91.41 91.30 87.34 91.19 91.03 91.03 100 G3821 92.46 92.24 92.63 88.61 92.24 92.35 92.85 91.74 100 G3825 91.41 90.53 93.40 87.78 91.74 91.85 92.13 91.47 92.07 100 G3826 92.02 91.80 91.80 88.72 91.41 91.63 91.69 91.63 92.57 92.07 100 G3845 90.97 91.14 92.63 87.89 95.60 95.82 91.85 90.75 92.18 91.52 91.30 100 G3850 92.18 92.29 92.29 87.40 91.69 91.96 92.68 91.36 92.24 91.69 92.13 91.85 100 ↵a Pairwise comparisons of GBV-C consensus sequences were generated by aligning sequences with ClustalW. After manual adjustment, the percent nucleotide identity was calculated from the resulting 1,800-bp alignment.
- TABLE 4
Factors associated with mortality in EBOV+ patientsa
Variable Univariate model Multivariate model Odds ratio (95% CI) P value Odds ratio (95% CI) P value Age (yr) 1.06 (1.01–1.11) 0.0124 1.09 (1.02–1.16) 0.0076 Sex (male) 0.56 (0.16–2.00) 0.3735 0.30 (0.05–1.91) 0.2028 GBV-C+ 0.25 (0.06–0.94) 0.0402 0.25 (0.05–1.20) 0.0835 ↵a Analyses are based on 49 patients for whom complete data were available. First-order interaction terms were not statistically significant and are therefore not included. P values are 2-tailed and based on chi-square tests from univariate and multivariate logistic regression, performed using the computer program R (46). Statistically significant P values are shown in bold. CI, confidence interval.
