Skip to main content
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems
  • Log in
  • My alerts
  • My Cart

Main menu

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Minireviews
    • JVI Classic Spotlights
    • Archive
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About JVI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
  • ASM
    • Antimicrobial Agents and Chemotherapy
    • Applied and Environmental Microbiology
    • Clinical Microbiology Reviews
    • Clinical and Vaccine Immunology
    • EcoSal Plus
    • Infection and Immunity
    • Journal of Bacteriology
    • Journal of Clinical Microbiology
    • Journal of Microbiology & Biology Education
    • Journal of Virology
    • mBio
    • Microbiology and Molecular Biology Reviews
    • Microbiology Resource Announcements
    • Microbiology Spectrum
    • Molecular and Cellular Biology
    • mSphere
    • mSystems

User menu

  • Log in
  • My alerts
  • My Cart

Search

  • Advanced search
Journal of Virology
publisher-logosite-logo

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Accepted Manuscripts
    • COVID-19 Special Collection
    • Minireviews
    • JVI Classic Spotlights
    • Archive
  • For Authors
    • Submit a Manuscript
    • Scope
    • Editorial Policy
    • Submission, Review, & Publication Processes
    • Organization and Format
    • Errata, Author Corrections, Retractions
    • Illustrations and Tables
    • Nomenclature
    • Abbreviations and Conventions
    • Publication Fees
    • Ethics Resources and Policies
  • About the Journal
    • About JVI
    • Editor in Chief
    • Editorial Board
    • For Reviewers
    • For the Media
    • For Librarians
    • For Advertisers
    • Alerts
    • RSS
    • FAQ
  • Subscribe
    • Members
    • Institutions
Spotlight

Articles of Significant Interest Selected from This Issue by the Editors

DOI: 10.1128/JVI.01773-14
  • Article
  • Info & Metrics
  • PDF
Loading

A North American Arenavirus Uses Human Transferrin Receptor

North American arenaviruses are generally considered nonpathogenic unlike the related New World arenaviruses that cause hemorrhagic fever. Moreover, New World arenaviruses with the capacity to engage human transferrin receptor 1 (TfR1) are more virulent compared with nonbinding strains. Zong et al. (p. 9418–9428) demonstrate that one North American arenavirus isolate closely related to Whitewater Arroyo virus, which has been implicated in fatal human cases, uses human TfR1 for attachment and entry. Additionally, modest changes in human TfR1 are sufficient to convert human TfR1 into a functional receptor for most North American arenaviruses. These findings suggest that North American arenaviruses have a greater potential to emerge as human pathogens than previously appreciated.

Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Replication

Influenza A virus exploits the host sumoylation machinery to modify its viral proteins, but the functional outcomes of viral sumoylation are not well understood. Han et al. (p. 9379–9390) demonstrate that influenza A virus nucleoprotein (NP) is a new sumoylation target. This modification is conserved among different influenza A virus subtypes and strains. Additionally, sumoylation of NP modulates intracellular NP trafficking and is essential for virus replication. This study suggests that influenza A virus relies on sumoylation to productively infect target cells.

Human Cytomegalovirus Proteins Are Required for Remodeling the Cellular Secretory Apparatus

Human cytomegalovirus (HCMV) remodels the cellular secretory apparatus to facilitate generation of the cytoplasmic virion assembly complex (cVAC). Yet, the HCMV proteins that regulate the cVAC are not known. Using small interfering RNA technology, Das and Ortiz et al. (p. 9086–9099) identified HCMV genes UL48, UL94, and UL103 as mediators of cVAC development. This work enhances an understanding of HCMV virion assembly and highlights potential antiviral targets.

Hepatitis B Virus Glycosylation, a Balance between Competing Functions

Glycosylated and nonglycosylated isoforms of the envelope proteins of hepatitis B virus are usually present on the virion surface. Julithe et al. (p. 9049–9059) show that glycosylation has a positive effect on virion assembly and immune escape. However, glycosylation has a detrimental effect on viral infectivity. Thus, partial glycosylation of the hepatitis B virus surface proteins reflects a fine-tuned balance between these competing functions.

Extraribosomal Function of Ribosomal Protein L13a in Antiviral Defense

The host immune system is capable of deploying a variety of antiviral defense mechanisms. Mazumder et al. (p. 9100–9110) show that ribosomal protein L13a is released from host cell ribosomes soon after respiratory syncytial virus (RSV) infection. Upon ribosomal release, L13a binds to a target sequence in the RSV matrix gene mRNA and prevents synthesis of the matrix protein, thereby reducing viral replication. This study illuminates a previously unappreciated mechanism of host defense and may facilitate design of RSV antiviral agents.

  • Copyright © 2014, American Society for Microbiology. All Rights Reserved.
PreviousNext
Back to top
Download PDF
Citation Tools
Articles of Significant Interest Selected from This Issue by the Editors
Journal of Virology Jul 2014, 88 (16) 8719; DOI: 10.1128/JVI.01773-14

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Print

Alerts
Sign In to Email Alerts with your Email Address
Email

Thank you for sharing this Journal of Virology article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Articles of Significant Interest Selected from This Issue by the Editors
(Your Name) has forwarded a page to you from Journal of Virology
(Your Name) thought you would be interested in this article in Journal of Virology.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Share
Articles of Significant Interest Selected from This Issue by the Editors
Journal of Virology Jul 2014, 88 (16) 8719; DOI: 10.1128/JVI.01773-14
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Top
  • Article
    • A North American Arenavirus Uses Human Transferrin Receptor
    • Sumoylation of Influenza A Virus Nucleoprotein Is Essential for Intracellular Trafficking and Virus Replication
    • Human Cytomegalovirus Proteins Are Required for Remodeling the Cellular Secretory Apparatus
    • Hepatitis B Virus Glycosylation, a Balance between Competing Functions
    • Extraribosomal Function of Ribosomal Protein L13a in Antiviral Defense
  • Info & Metrics
  • PDF

Related Articles

Cited By...

About

  • About JVI
  • Editor in Chief
  • Editorial Board
  • Policies
  • For Reviewers
  • For the Media
  • For Librarians
  • For Advertisers
  • Alerts
  • RSS
  • FAQ
  • Permissions
  • Journal Announcements

Authors

  • ASM Author Center
  • Submit a Manuscript
  • Article Types
  • Ethics
  • Contact Us

Follow #Jvirology

@ASMicrobiology

       

 

JVI in collaboration with

American Society for Virology

ASM Journals

ASM journals are the most prominent publications in the field, delivering up-to-date and authoritative coverage of both basic and clinical microbiology.

About ASM | Contact Us | Press Room

 

ASM is a member of

Scientific Society Publisher Alliance

 

American Society for Microbiology
1752 N St. NW
Washington, DC 20036
Phone: (202) 737-3600

Copyright © 2021 American Society for Microbiology | Privacy Policy | Website feedback

Print ISSN: 0022-538X; Online ISSN: 1098-5514