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Genetic Diversity and Evolution

Continuing Reassortment Leads to the Genetic Diversity of Influenza Virus H7N9 in Guangdong, China

Jing Lu, Jie Wu, Xianqiao Zeng, Dawei Guan, Lirong Zou, Lina Yi, Lijun Liang, Hanzhong Ni, Min Kang, Xin Zhang, Haojie Zhong, Xiang He, Corina Monagin, Jinyan Lin, Changwen Ke
A. García-Sastre, Editor
Jing Lu
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
bGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Jie Wu
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Xianqiao Zeng
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Dawei Guan
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Lirong Zou
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Lina Yi
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
bGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Lijun Liang
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Hanzhong Ni
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Min Kang
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Xin Zhang
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Haojie Zhong
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Xiang He
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
bGuangdong Provincial Institution of Public Health, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Corina Monagin
cMetabiota Inc., San Francisco, California, USA
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Jinyan Lin
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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Changwen Ke
aGuangdong Provincial Center for Disease Control and Prevention, Guangzhou, China
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A. García-Sastre
Roles: Editor
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DOI: 10.1128/JVI.00630-14
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    FIG 1

    Distribution (A) and timeline of identification (B) of influenza A H7N9 and H9N2 viruses from LPM and clinical patients in Guangdong Province, China, in 2013. The 10 provinces and/or cities that reported H7N9 virus cases between March and May 2013 are marked in red (A).

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    FIG 2

    Maximum-likelihood phylogenetic trees for the HA, NA, M, PA, NS, NP, PB1, and PB2 genes of H7N9 isolates. The viruses isolated in this study are marked as in Fig. 1. The separated clusters of major circulating H7N9 viruses and the A/Guangdong/1/2013 (H7N9) virus are highlighted in blue and red, respectively. Supporting bootstrap values greater than 70 are shown.

Tables

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  • TABLE 1

    Environmental surveillance of avian influenza viruses in Guangdong Province from April to May 2013

    CityNo. of poultry marketsNo. of samples collectedNo. of positive samples
    TotalH5H7H9H5/H9Hx
    Jieyang4140566011138
    Zhongshan5140550038017
    Zhuhai5140530033218
    Qingyuan514052003049
    Shenzhen414044502478
    Zhanjiang4140380014024
    Shantou5140300019011
    Shaoguan6210330017016
    Zhaoqing5140271013013
    Shanwei41202290409
    Meizhou619928021709
    Heyuan414018004014
    Yunfu414017101204
    Jiangmen514016001006
    Huizhou41201210731
    Yangjiang41401100209
    Shunde128200200
    Foshan5152900801
    Maoming4120500500
    Dongguan6140200101
    Chaozhou5172000000
    Guangzhou11294490030019
    Total1063,23557923227413267

Additional Files

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    Files in this Data Supplement:

    • Supplemental file 1 -

      Table S1 (Avian influenza viruses isolated and sequenced in this study.)

      Table S2 (Accession numbers of the HA, NA, M, PA, NS, NP, PB1, and PB2 genes included in the phylogenetic trees shown in Figure 2.)

      Figure S1–S4 (Phylogenetic trees of the NS, NP, PB1, and PB2 genes.)

      PDF, 757K

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Continuing Reassortment Leads to the Genetic Diversity of Influenza Virus H7N9 in Guangdong, China
Jing Lu, Jie Wu, Xianqiao Zeng, Dawei Guan, Lirong Zou, Lina Yi, Lijun Liang, Hanzhong Ni, Min Kang, Xin Zhang, Haojie Zhong, Xiang He, Corina Monagin, Jinyan Lin, Changwen Ke
Journal of Virology Jul 2014, 88 (15) 8297-8306; DOI: 10.1128/JVI.00630-14

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Continuing Reassortment Leads to the Genetic Diversity of Influenza Virus H7N9 in Guangdong, China
Jing Lu, Jie Wu, Xianqiao Zeng, Dawei Guan, Lirong Zou, Lina Yi, Lijun Liang, Hanzhong Ni, Min Kang, Xin Zhang, Haojie Zhong, Xiang He, Corina Monagin, Jinyan Lin, Changwen Ke
Journal of Virology Jul 2014, 88 (15) 8297-8306; DOI: 10.1128/JVI.00630-14
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